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Mechanisms of PIEZO Channel Inactivation
Version 1
: Received: 22 August 2023 / Approved: 22 August 2023 / Online: 23 August 2023 (07:52:43 CEST)
A peer-reviewed article of this Preprint also exists.
Zhou, Z.; Martinac, B. Mechanisms of PIEZO Channel Inactivation. Int. J. Mol. Sci. 2023, 24, 14113. Zhou, Z.; Martinac, B. Mechanisms of PIEZO Channel Inactivation. Int. J. Mol. Sci. 2023, 24, 14113.
Abstract
PIEZO channels PIEZO1 and PIEZO2 are the newly identified mechanosensitive, non-selective cation channels permeable to Ca2+. In higher vertebrates, PIEZO1 expresses ubiquitously in most of the tissues and cells while PIEZO2 expresses more specifically in the peripheral sensory neurons. PIEZO channels contribute to a wide range of biological behaviors and developmental processes, therefore driving a significant attention in the effort to understand their molecular properties. One prominent property of PIEZO channels is their rapid inactivation, which manifests itself as a decrease of channel open probability in the presence of a sustained mechanical stimulus. Lack of the PIEZO channel inactivation is linked to various mechanopathologies emphasizing the significance of studying this PIEZO channel property and the factors affecting it. In the present review, we discuss the mechanisms underlying the PIEZO channel inactivation, its modulation by interaction of the channels with lipids and/or proteins, and how the changes of PIEZO inactivation by the channel mutations can cause a variety of diseases in animals and humans.
Keywords
mechanosensitive channels; mechanopathologies; force-from-lipids; TMEM150C; STOML3; MDFIC; MDFI
Subject
Biology and Life Sciences, Life Sciences
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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