Non-invasive Multiregional Tumor Sampling Using Magnetic Nanoparticle-Loaded Macrophages

Michael Renteln

doi:10.20944/preprints202308.1536.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 21 August 2023 / Approved: 21 August 2023 / Online: 22 August 2023 (07:58:07 CEST)
Version 2 : Received: 5 September 2023 / Approved: 6 September 2023 / Online: 7 September 2023 (02:54:00 CEST)
Version 3 : Received: 31 December 2023 / Approved: 2 January 2024 / Online: 2 January 2024 (10:00:17 CET)
Version 4 : Received: 4 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (13:52:59 CET)
Version 5 : Received: 21 March 2024 / Approved: 22 March 2024 / Online: 22 March 2024 (12:06:13 CET)

Some tumors occur in anatomical regions that are hard to biopsy with a needle. Such regions include the brain, spinal cord, liver, and lungs. For the latter two, magnetic nanoparticle-loaded macrophages could be intravenously infused and driven via an MRI machine into the tumor or tumors. Once there, they can be induced to phagocytose whole tumor cells. They would keep their target in a non-digested form by inhibiting phagosome maturation - and be directed via magnetotaxis or chemotaxis to an extraction point in the body where they can be more easily collected via needle.

Multiregional sequencing; multi-sample sequencing; targeted cancer therapy; OVERCOME; macrophage magnetotaxis

Medicine and Pharmacology, Oncology and Oncogenics

Comment 1

Received: 7 September 2023
Commenter: Michael Renteln
Commenter's Conflict of Interests: Author

Comment: Edited much of it. Made it clear that two of the possible strategies could involve an unacceptably high risk of causing metastasis.

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Non-invasive Multiregional Tumor Sampling Using Magnetic Nanoparticle-Loaded Macrophages

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