Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Microbiota-Mediated Tumor Microenvironment: Exploring the Impact on Cancer Development

Version 1 : Received: 8 August 2023 / Approved: 9 August 2023 / Online: 10 August 2023 (10:17:59 CEST)

How to cite: Patil, A.; Singh, N. Microbiota-Mediated Tumor Microenvironment: Exploring the Impact on Cancer Development. Preprints 2023, 2023080784. https://doi.org/10.20944/preprints202308.0784.v1 Patil, A.; Singh, N. Microbiota-Mediated Tumor Microenvironment: Exploring the Impact on Cancer Development. Preprints 2023, 2023080784. https://doi.org/10.20944/preprints202308.0784.v1

Abstract

Tumor-associated microbiota refers to the community of microorganisms found in tumors and is part of the larger tumor microenvironment (TME). The discovery of the complex relationship between these microbial populations and the growth of cancer has prompted the creation of cutting-edge tailored methods to cancer treatment. In recent years, microbiota profiling's potential as a diagnostic, prognostic, and therapeutic optimization tool has been increasingly apparent. The diagnostic and prognostic use of microbiota profiling is explored in this abstract. Microbiota profiling shows potential for early cancer detection, improved risk stratification, and greater prediction of treatment outcomes by identifying different microbial signatures associated with early-stage tumors, aggressive characteristics, and responses to treatment. In addition, this method provides the way for individualized medicinal approaches based on an individual's specific microbiome.Microbiota profiling is investigated as a means of customizing treatment plans, illuminating how knowledge of an individual's microbiome might direct the development of individualized treatments and multimodal approaches. These kind of interventions have the potential to herald in a new era of patient-centered oncology care by increasing treatment efficacy while decreasing side effects. Despite significant promise, microbiota profiling has obstacles that must be overcome before it can be successfully translated into therapeutic practice. This abstract highlights the revolutionary potential of microbiota-based approaches in cancer care and the need for ongoing research and technology improvements to harness the power of the tumor-associated microbiome for improved patient outcomes.

Keywords

Tumor; microbiota; microbiome; diagnostics

Subject

Biology and Life Sciences, Immunology and Microbiology

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