Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas

Jianrong Guo
ORCID logo ,
Shoucheng Feng
,
Hong Liu
,
Chao Ding
,
Yukai Jin
,
Xiaojiang Chen
,
Yudong Ling
,
Yi Zeng
,
Zhuopeng Chen
* ,
Hao Long
* ,
Haibo Qiu
*
Version 1 : Received: 4 August 2023 / Approved: 7 August 2023 / Online: 7 August 2023 (11:48:02 CEST)

A peer-reviewed article of this Preprint also exists.

Guo, J.; Feng, S.; Liu, H.; Chen, Z.; Ding, C.; Jin, Y.; Chen, X.; Ling, Y.; Zeng, Y.; Long, H.; Qiu, H. TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas. Biomolecules 2023, 13, 1298. Guo, J.; Feng, S.; Liu, H.; Chen, Z.; Ding, C.; Jin, Y.; Chen, X.; Ling, Y.; Zeng, Y.; Long, H.; Qiu, H. TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas. Biomolecules 2023, 13, 1298.

Abstract

This study investigates the expression and prognostic value of TRIM6 in gliomas, the most prevalent primary brain and spinal cord tumors. Our results show that TRIM6 is predominantly overexpressed in glioma tissues and is associated with reduced overall survival, disease-specific survival, and progression-free interval. Furthermore, TRIM6 expression is correlated with WHO grade and primary treatment outcomes. Functional analysis indicates that interactions between cytokines and their receptors play a critical role in the prognosis of glioma patients. A protein-protein interaction network reveals 10 hub genes closely linked to cytokine-cytokine receptor interaction. In vitro experiments demonstrate that silencing TRIM6 impairs the proliferation, invasion, and migration of glioma cells, while overexpressing TRIM6 enhances these abilities. Additionally, TRIM6 expression is positively associated with the abundance of innate immune cells and negatively associated with the abundance of adaptive immune cells. In summary, TRIM6 is significantly upregulated in gliomas and linked to poor prognosis, making it a potential diagnostic and prognostic biomarker. TRIM6 plays a crucial role in promoting cell viability, clonogenic potential, migration, and invasion in glioma cells. It may regulate glioma progression by modulating cytokine-cytokine receptor interaction, leading to an inflammatory response and an imbalance in immunomodulation, thereby representing a potential therapeutic target.

Keywords

TRIM6; Gliomas; Prognostic Biomarker; Cytokine-cytokine receptor interaction; Immune Infiltrates

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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