Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Novel Therapeutic Opportunities for Neurodegenerative Diseases with Mesenchymal Stem Cells: The Focus on Modulating the Blood-Brain Barrier

Pablo Vargas-Rodríguez
# ORCID logo ,
Alejandro Cuenca-Martagón
# ,
Julia Castillo-González
ORCID logo ,
Ignacio Serrano-Martínez
ORCID logo ,
Raúl M Luque
,
Mario Delgado
ORCID logo ,
Elena González-Rey
*
#
These authors contributed equally to this work
Version 1 : Received: 4 August 2023 / Approved: 4 August 2023 / Online: 7 August 2023 (05:26:58 CEST)

A peer-reviewed article of this Preprint also exists.

Vargas-Rodríguez, P.; Cuenca-Martagón, A.; Castillo-González, J.; Serrano-Martínez, I.; Luque, R.M.; Delgado, M.; González-Rey, E. Novel Therapeutic Opportunities for Neurodegenerative Diseases with Mesenchymal Stem Cells: The Focus on Modulating the Blood-Brain Barrier. Int. J. Mol. Sci. 2023, 24, 14117. Vargas-Rodríguez, P.; Cuenca-Martagón, A.; Castillo-González, J.; Serrano-Martínez, I.; Luque, R.M.; Delgado, M.; González-Rey, E. Novel Therapeutic Opportunities for Neurodegenerative Diseases with Mesenchymal Stem Cells: The Focus on Modulating the Blood-Brain Barrier. Int. J. Mol. Sci. 2023, 24, 14117.

Abstract

Neurodegenerative diseases encompass a broad spectrum of profoundly disabling disorders that impact millions of individuals globally. While their underlying causes and pathophysiol-ogy display considerable diversity and remain incompletely understood, a mounting body of evidence indicates that the disruption of blood-brain barrier (BBB) permeability, resulting in brain damage and neuroinflammation, constitutes a shared characteristic among them. Con-sequently, targeting the BBB has emerged as an innovative therapeutic strategy for address-ing neurological diseases. Within this review, we not only explore the neuroprotective, neu-rotrophic, and immunomodulatory benefits of mesenchymal stem cells (MSCs) in combating neurodegeneration but also delve into their recent role in modulating the BBB. We will delve into the cellular and molecular mechanisms through which MSC treatment impacts primary age-related neurological disorders like Alzheimer’s disease, Parkinson’s disease, and stroke as well as immune-mediated conditions such as multiple sclerosis. Our focus will center on how MSCs participate in the modulation of cell transporters, matrix remodeling, stabilization of cell-junction components, and restoration of BBB network integrity in these pathological con-texts.

Keywords

blood-brain barrier; mesenchymal stem cell; neurodegenerative diseases; Alzheimer’s disease; neuroinflammation; Parkinson’s disease; multiple sclerosis; stroke

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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