Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In Vivo Assessment of Acute Toxicity and Immunotoxicity of Quantum Dots with Different Physicochemical Properties

Evgeniia Gerasimovich
ORCID logo ,
Svetlana Bozrova
,
Maria Baryshnikova
,
Zinaida Sokolova
,
Pavel Samokhvalov
ORCID logo ,
Alexander Karaulov
ORCID logo ,
Igor Nabiev
* ORCID logo ,
Alyona Sukhanova
* ORCID logo
Version 1 : Received: 30 July 2023 / Approved: 31 July 2023 / Online: 1 August 2023 (11:56:40 CEST)

How to cite: Gerasimovich, E.; Bozrova, S.; Baryshnikova, M.; Sokolova, Z.; Samokhvalov, P.; Karaulov, A.; Nabiev, I.; Sukhanova, A. In Vivo Assessment of Acute Toxicity and Immunotoxicity of Quantum Dots with Different Physicochemical Properties. Preprints 2023, 2023080032. https://doi.org/10.20944/preprints202308.0032.v1 Gerasimovich, E.; Bozrova, S.; Baryshnikova, M.; Sokolova, Z.; Samokhvalov, P.; Karaulov, A.; Nabiev, I.; Sukhanova, A. In Vivo Assessment of Acute Toxicity and Immunotoxicity of Quantum Dots with Different Physicochemical Properties. Preprints 2023, 2023080032. https://doi.org/10.20944/preprints202308.0032.v1

Abstract

Fluorescent semiconductor nanocrystals called quantum dots (QDs) have gained attention in biomedical applications, including imaging, molecular tracking, and drug delivery, due to their unique optical properties. However, their use is limited because of safety issues. This study was aimed at assessment the acute toxicity of QDs with different core chemical compositions and surface charges in mice. In addition, the immunotoxicity of CdSe/ZnS QDs was estimated. CdSe/ZnS, PbS/CdS/ZnS, and CuInS2/ZnS QDs were synthesized and modified with PEG derivatives. The hydrodynamic diameters and surface charges of solubilized QDs were characterized. The QD acute toxicity has been shown to depend on both surface charge and core composition. The immunotoxicity of CdSe/ZnS-PEG-OH QDs in mice was assessed after a single intravenous administration of 0.2 LD100 of the QDs. The QDs have been found to increase the spleen weight and cause spleen, thymus, and bone marrow cell depletion. However, these changes are reversible. A transient increase in the levels of proinflammatory cytokines (MCP1 and IL-6) indicates an acute inflammatory response to a single low dose of QDs. Thus, systemic comparative analysis of QD toxicity has shown how the QD core composition and surface properties affect living organisms.

Keywords

quantum dots; semiconductor nanocrystals; acute toxicity; immunotoxicity; cytokine profile

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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