PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Variability in the Bioactivities of Wild Populations of Baccharis crispa Spreng. (Asteraceae) from Córdoba, Argentina: Screening of Cytotoxic and Antiviral Activity
Version 1
: Received: 28 July 2023 / Approved: 31 July 2023 / Online: 1 August 2023 (10:44:28 CEST)
How to cite:
Lingua, G.; Chaves, A.G.; Aguilar, J.J.; Martinez, F.; Torres, L.; Lucini, E.; Contigiani, M.; Nuñez Montoya, S.; Konigheim, B.S. Variability in the Bioactivities of Wild Populations of Baccharis crispa Spreng. (Asteraceae) from Córdoba, Argentina: Screening of Cytotoxic and Antiviral Activity. Preprints2023, 2023072157. https://doi.org/10.20944/preprints202307.2157.v1
Lingua, G.; Chaves, A.G.; Aguilar, J.J.; Martinez, F.; Torres, L.; Lucini, E.; Contigiani, M.; Nuñez Montoya, S.; Konigheim, B.S. Variability in the Bioactivities of Wild Populations of Baccharis crispa Spreng. (Asteraceae) from Córdoba, Argentina: Screening of Cytotoxic and Antiviral Activity. Preprints 2023, 2023072157. https://doi.org/10.20944/preprints202307.2157.v1
Lingua, G.; Chaves, A.G.; Aguilar, J.J.; Martinez, F.; Torres, L.; Lucini, E.; Contigiani, M.; Nuñez Montoya, S.; Konigheim, B.S. Variability in the Bioactivities of Wild Populations of Baccharis crispa Spreng. (Asteraceae) from Córdoba, Argentina: Screening of Cytotoxic and Antiviral Activity. Preprints2023, 2023072157. https://doi.org/10.20944/preprints202307.2157.v1
APA Style
Lingua, G., Chaves, A.G., Aguilar, J.J., Martinez, F., Torres, L., Lucini, E., Contigiani, M., Nuñez Montoya, S., & Konigheim, B.S. (2023). Variability in the Bioactivities of Wild Populations of <em>Baccharis crispa</em> Spreng. (<em>Asteraceae</em>) from Córdoba, Argentina: Screening of Cytotoxic and Antiviral Activity. Preprints. https://doi.org/10.20944/preprints202307.2157.v1
Chicago/Turabian Style
Lingua, G., Susana Nuñez Montoya and Brenda S. Konigheim. 2023 "Variability in the Bioactivities of Wild Populations of <em>Baccharis crispa</em> Spreng. (<em>Asteraceae</em>) from Córdoba, Argentina: Screening of Cytotoxic and Antiviral Activity" Preprints. https://doi.org/10.20944/preprints202307.2157.v1
Abstract
Medicinal plants are being tested as options to prevent infectious diseases in many countries. Baccharis crispa Spreng. (Asteraceae), is a native medicinal species widely used throughout South America. Our objective was to evaluate the antiviral activity of four wild populations of B. crispa from the province of Córdoba (Argentina) and determine if there is variability between them. The cytotoxicity of the extracts (chlorofom, ethanol and aquose) was evaluated by the neutral red uptake method. Using the plaque-forming unit reduction assay, virucidal and antiviral activity against Herpes Simplex type 1 and Chikungunya viruses were tested. Phytochemical screening of each extract was also performed. Puesto Pedernera (PP) population showed the best antiviral and virucidal effect, standing out the ethanolic extract as the least toxic and with the best inhibitory activity against both viral models. Villa del Parque (VP) population was inactive, regardless of the extract and the virus tested. The results revealed that extracts bioactivities vary significantly depending on the geographic area of collection, with PP and VP populations showing the most significant variability, not only in activity but also in chemical composition. These findings support the potential use of extracts as a source of therapeutic agents against different viruses.
Keywords
natural products; population variability; bioactivities; Herpes Simplex virus; Chikungunya virus
Subject
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
