Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

CETP Expression in Bone Marrow Derived Cells Reduces Inflammatory Features of Atherosclerosis in Hypercholesterolemic Mice

Thiago Rentz
ORCID logo ,
Gabriel G. Dorighello
ORCID logo ,
Renata R. Dos Santos
,
Lohana M. Barreto
,
Israelle N. Freitas
,
Daniela S. Razolli
ORCID logo ,
Helena C. F. Oliveira
* ORCID logo
Version 1 : Received: 26 July 2023 / Approved: 27 July 2023 / Online: 27 July 2023 (13:38:57 CEST)

A peer-reviewed article of this Preprint also exists.

Rentz, T.; Dorighello, G.G.; dos Santos, R.R.; Barreto, L.M.; Freitas, I.N.; Lazaro, C.M.; Razolli, D.S.; Cazita, P.M.; Oliveira, H.C.F. CETP Expression in Bone-Marrow-Derived Cells Reduces the Inflammatory Features of Atherosclerosis in Hypercholesterolemic Mice. Biomolecules 2023, 13, 1556. https://doi.org/10.3390/biom13101556 Rentz, T.; Dorighello, G.G.; dos Santos, R.R.; Barreto, L.M.; Freitas, I.N.; Lazaro, C.M.; Razolli, D.S.; Cazita, P.M.; Oliveira, H.C.F. CETP Expression in Bone-Marrow-Derived Cells Reduces the Inflammatory Features of Atherosclerosis in Hypercholesterolemic Mice. Biomolecules 2023, 13, 1556. https://doi.org/10.3390/biom13101556

Abstract

CETP activity reduces plasma HDL-cholesterol concentrations, a correlate of increased risk of atherosclerotic events. However, our recent findings suggest that CETP expression in macrophages promotes an intracellular antioxidant state, reduces free cholesterol accumulation and phagocytosis, and attenuates pro-inflammatory gene expression. To determine whether CETP expression in macrophages affects atherosclerosis development, we transplanted bone marrow from transgenic mice expressing simian CETP or non-expressing littermates into hypercholesterolemic LDL receptor deficient mice. CETP expression did not change lipid-stained lesion areas but decreased macrophage content (CD68), neutrophil accumulation (LY6G) and aorta content of young male transplanted mice and decreased LY6G, TNF-α, iNOS and nitrotyrosine (3-NT) in aged female transplanted mice. These findings suggest that CETP expression in bone marrow-derived cells reduces inflammatory features of atherosclerosis. These novel mechanistic observations may help explain the failure of CETP inhibitors to reduce atherosclerotic events in humans.

Keywords

CETP; atherosclerosis; inflammation; macrophages; nicotinamide nucleotide transhydrogenase; LDL receptor knockout mice

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.