Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer

Seyed Pedram Mirmazhari; Mohammad Javad Abdi; Amir Hosein Mosadeghrad; Reza Abedini Bonab; Arman Amani Babadi; Garshasb Rigi; Seyedeh Zahra Shahrokhi; Mohsen Chamanara; Nicola Amodio; Reza Heidari

doi:10.20944/preprints202307.1901.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202307.1901.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer

Seyed Pedram Mirmazhari

Mohammad Javad Abdi

Amir Hosein Mosadeghrad

Reza Abedini Bonab

Arman Amani Babadi

Garshasb Rigi

Seyedeh Zahra Shahrokhi

Mohsen Chamanara

^* ,

Nicola Amodio

^* ,

Reza Heidari

Version 1 : Received: 26 July 2023 / Approved: 27 July 2023 / Online: 27 July 2023 (10:23:16 CEST)

How to cite: Mirmazhari, S.P.; Abdi, M.J.; Mosadeghrad, A.H.; Abedini Bonab, R.; Amani Babadi, A.; Rigi, G.; Shahrokhi, S.Z.; Chamanara, M.; Amodio, N.; Heidari, R. Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer. Preprints 2023, 2023071901. https://doi.org/10.20944/preprints202307.1901.v1 Mirmazhari, S.P.; Abdi, M.J.; Mosadeghrad, A.H.; Abedini Bonab, R.; Amani Babadi, A.; Rigi, G.; Shahrokhi, S.Z.; Chamanara, M.; Amodio, N.; Heidari, R. Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer. Preprints 2023, 2023071901. https://doi.org/10.20944/preprints202307.1901.v1

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MDPI and ACS Style

Mirmazhari, S.P.; Abdi, M.J.; Mosadeghrad, A.H.; Abedini Bonab, R.; Amani Babadi, A.; Rigi, G.; Shahrokhi, S.Z.; Chamanara, M.; Amodio, N.; Heidari, R. Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer. Preprints 2023, 2023071901. https://doi.org/10.20944/preprints202307.1901.v1

APA Style

Mirmazhari, S.P., Abdi, M.J., Mosadeghrad, A.H., Abedini Bonab, R., Amani Babadi, A., Rigi, G., Shahrokhi, S.Z., Chamanara, M., Amodio, N., & Heidari, R. (2023). Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer. Preprints. https://doi.org/10.20944/preprints202307.1901.v1

Chicago/Turabian Style

Mirmazhari, S.P., Nicola Amodio and Reza Heidari. 2023 "Unraveling the Complex Interplay between lncRNAs and Myc in Breast Cancer" Preprints. https://doi.org/10.20944/preprints202307.1901.v1

Abstract

The Myc gene, widely studied in numerous cancer types, serves as a pivotal regulator of crucial cellular processes implicated in tumorigenesis, such as cell growth, proliferation, invasion, metastasis, and therapy resistance. LncRNAs have been identified as relevant partners of Myc. LncRNAs modulate chromatin structure and function, transcription, splicing, stability, and translation of mRNAs, thereby emerging as pivotal regulators in cell differentiation, metabolism, signaling. An intricate crosstalk exists between Myc and lncRNAs in a wide range of cancers, wherein they can physically and functionally interact through direct and indirect mechanisms. Some lncRNAs can regulate Myc activity at post-transcriptional level, affecting its stability, translation, or interactions with other proteins, thus acting as oncogenes, while others act as tumor suppressors. On the other hand, Myc can target numerous lncRNA genes and modulate their expression, affecting the expression of downstream targets involved in tumorigenesis. Given the significant role of the Myc-lncRNA network in various cancer types, exploring therapeutic strategies targeting these crucial cellular regulators is of utmost importance. This review article focuses on breast cancer, analyzing those lncRNAs influencing Myc as well as the Myc-regulated lncRNAs.

Keywords

MYC; LncRNAs; miRNA; Breast Cancer

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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