Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In Vitro and In Silico Activities of E. radiata and E. cinerea as an Enhancer of Antibacterial, Antioxidant, and Anti-Inflammatory Agents

Meriem Elkolli
ORCID logo ,
Elkolli Hayet
,
Farid Ataya
ORCID logo ,
Mounir M. Salem-Bekhit
* ,
Barbara Ernst
,
Yacine Benguerba
* ORCID logo
Version 1 : Received: 26 July 2023 / Approved: 27 July 2023 / Online: 27 July 2023 (08:19:02 CEST)

A peer-reviewed article of this Preprint also exists.

Elkolli, H.; Elkolli, M.; Ataya, F.S.; Salem-Bekhit, M.M.; Zahrani, S.A.; Abdelmageed, M.W.M.; Ernst, B.; Benguerba, Y. In Vitro and In Silico Activities of E. radiata and E. cinerea as an Enhancer of Antibacterial, Antioxidant, and Anti-Inflammatory Agents. Molecules 2023, 28, 7153. Elkolli, H.; Elkolli, M.; Ataya, F.S.; Salem-Bekhit, M.M.; Zahrani, S.A.; Abdelmageed, M.W.M.; Ernst, B.; Benguerba, Y. In Vitro and In Silico Activities of E. radiata and E. cinerea as an Enhancer of Antibacterial, Antioxidant, and Anti-Inflammatory Agents. Molecules 2023, 28, 7153.

Abstract

Eucalyptus, a therapeutic plant mentioned in the ancient Algerian pharmacopeia, specifically two species belonging to the Myrtaceae family - E. radiata and E. cinerea, were investigated in this study for their antibacterial, antioxidant, and anti-inflammatory properties. The study used aqueous extracts (AE) obtained from these plants, and the extraction yields were found to be dif-ferent. The in vitro antibacterial activity was evaluated using a disc diffusion assay against three typical bacterial strains. The results showed that E. radiata EAq was effective against all three strains, while E. cinerea EAq was only effective against E. coli. Both extracts displayed significant antioxidant activity compared to BHT. The anti-inflammatory impact was evaluated using a pro-tein (BSA) inhibition denaturation test. The E. radiata extract was found to inhibit inflammation by 75% at a concentration of 250 g/ml, significantly higher than the placebo. Ellagic acid, a pri-mary phytochemical found in the extracts, demonstrated noteworthy toxic and pharmacokinetic characteristics and a maximum binding energy of -7.53 kcal/mol for its anti-TyrRS activity in sili-co. The study suggests that the extracts and their primary phytochemicals could enhance the effi-cacy of antibiotics, antioxidants, and non-steroidal anti-inflammatory drugs (NSAIDs). As phar-maceutical engineering experts, we believe this research contributes to developing natural-based drugs with potential therapeutic benefits.

Keywords

antibacterial; antioxidant; anti-inflammatory activity; E. radiata; E. cinerea

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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