Version 1
: Received: 26 July 2023 / Approved: 26 July 2023 / Online: 28 July 2023 (10:12:08 CEST)
How to cite:
Sahoo, O.S.; Pethusamy, K.; Nayek, A.; Minocha, R.; Dhar, R.; Karmakar, S. The Paradigm of Immune Dysregulation in COVID-19 Infection. Preprints2023, 2023071880. https://doi.org/10.20944/preprints202307.1880.v1
Sahoo, O.S.; Pethusamy, K.; Nayek, A.; Minocha, R.; Dhar, R.; Karmakar, S. The Paradigm of Immune Dysregulation in COVID-19 Infection. Preprints 2023, 2023071880. https://doi.org/10.20944/preprints202307.1880.v1
Sahoo, O.S.; Pethusamy, K.; Nayek, A.; Minocha, R.; Dhar, R.; Karmakar, S. The Paradigm of Immune Dysregulation in COVID-19 Infection. Preprints2023, 2023071880. https://doi.org/10.20944/preprints202307.1880.v1
APA Style
Sahoo, O.S., Pethusamy, K., Nayek, A., Minocha, R., Dhar, R., & Karmakar, S. (2023). The Paradigm of Immune Dysregulation in COVID-19 Infection. Preprints. https://doi.org/10.20944/preprints202307.1880.v1
Chicago/Turabian Style
Sahoo, O.S., Ruby Dhar and Subhradip Karmakar. 2023 "The Paradigm of Immune Dysregulation in COVID-19 Infection" Preprints. https://doi.org/10.20944/preprints202307.1880.v1
Abstract
The COVID-19 pandemic cost 7-8 million deaths worldwide, creating an unprecedented health and economic crisis. Affecting 700 million people globally, the magnitude of this pandemic is far from anything that humanity has encountered in recent times. A detailed investigation revealed that more than the SARS-CoV2 virus, the hyperactive immune system mediated injury as the real cause of mortality. Cytokine storm following viral infection leads to the surge of proinflammatory cytokines resulting in ARDS and lung injury. Anti-inflammatory intervention with anti-IL6 (anti-IL-6 receptor monoclonal antibodies (mAbs) (e.g., sarilumab, tocilizumab) and anti-IL-6 mAbs (i.e., siltuximab) and /or steroid-based approach lead to substantial protection and prevent death thereby implying the role of inflammation in COVID-19. In this short review, we summarized the dysregulated immune system in COVID-19 infection, investigating in detail the virus–host immune cross talks and presenting the possibilities of therapeutic intervention.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
