Is Modern Medicine in Need of an Overhydration Marker in Kidney Failure? The Accuracy of Available Fluid Overload Markers and the Potential of the New Ones

Barbara Emilia Nikitiuk; Alicja Rydzewska-Rosołowska; Katarzyna Kakareko; Irena Głowińska; Tomasz Hryszko

doi:10.20944/preprints202307.1818.v2

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preprints.org > medicine and pharmacology > internal medicine > doi: 10.20944/preprints202307.1818.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Is Modern Medicine in Need of an Overhydration Marker in Kidney Failure? The Accuracy of Available Fluid Overload Markers and the Potential of the New Ones

Barbara Emilia Nikitiuk

Alicja Rydzewska-Rosołowska

^* ,

Katarzyna Kakareko

Irena Głowińska

Tomasz Hryszko

Version 1 : Received: 24 July 2023 / Approved: 9 August 2023 / Online: 9 August 2023 (12:44:33 CEST)
Version 2 : Received: 13 September 2023 / Approved: 14 September 2023 / Online: 15 September 2023 (11:01:27 CEST)
Version 3 : Received: 4 October 2023 / Approved: 5 October 2023 / Online: 5 October 2023 (14:28:42 CEST)

How to cite: Nikitiuk, B.E.; Rydzewska-Rosołowska, A.; Kakareko, K.; Głowińska, I.; Hryszko, T. Is Modern Medicine in Need of an Overhydration Marker in Kidney Failure? The Accuracy of Available Fluid Overload Markers and the Potential of the New Ones. Preprints 2023, 2023071818. https://doi.org/10.20944/preprints202307.1818.v2 Nikitiuk, B.E.; Rydzewska-Rosołowska, A.; Kakareko, K.; Głowińska, I.; Hryszko, T. Is Modern Medicine in Need of an Overhydration Marker in Kidney Failure? The Accuracy of Available Fluid Overload Markers and the Potential of the New Ones. Preprints 2023, 2023071818. https://doi.org/10.20944/preprints202307.1818.v2

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MDPI and ACS Style

Nikitiuk, B.E.; Rydzewska-Rosołowska, A.; Kakareko, K.; Głowińska, I.; Hryszko, T. Is Modern Medicine in Need of an Overhydration Marker in Kidney Failure? The Accuracy of Available Fluid Overload Markers and the Potential of the New Ones. Preprints 2023, 2023071818. https://doi.org/10.20944/preprints202307.1818.v2

APA Style

Nikitiuk, B.E., Rydzewska-Rosołowska, A., Kakareko, K., Głowińska, I., & Hryszko, T. (2023). Is Modern Medicine in Need of an Overhydration Marker in Kidney Failure? The Accuracy of Available Fluid Overload Markers and the Potential of the New Ones. Preprints. https://doi.org/10.20944/preprints202307.1818.v2

Chicago/Turabian Style

Nikitiuk, B.E., Irena Głowińska and Tomasz Hryszko. 2023 "Is Modern Medicine in Need of an Overhydration Marker in Kidney Failure? The Accuracy of Available Fluid Overload Markers and the Potential of the New Ones" Preprints. https://doi.org/10.20944/preprints202307.1818.v2

Abstract

Overhydration (OH) is a common medical problem found in patients with kidney or heart failure, but still a specific marker has not been found. Clinicians today use bioimpedance spectroscopy (BIS), ultrasound (US) markers of fluid overload or markers of heart and kidney function like NT-pro-BNP, GFR or creatinine levels. New serum markers such as Ca-125, Galectin-3 (Gal-3), Adrenomedullin (AMD) and Urocortin-2 (UCN-2), are being researched with promising results. The need to discover a more precise marker of overhydration is dire mainly because physical examination is extremely imprecise. Signs and symptoms of fluid overload like edema or gradual increase of body mass are not always present, especially in patients with chronic kidney disease. This review paper summarizes actual knowledge of a patient's hydration status estimation focusing especially on kidney diseases.

Keywords

Fluid status 1; overhydration 2; hydration status 3; renal failure 4; kidney failure 5; heart failure 6; Ca-125 7; NT-pro-BNP 8; VEXUS 9; BIS 10

Subject

Medicine and Pharmacology, Internal Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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