Genetic and Epigenetic Mechanisms of Psoriasis

Laura Mateu-Arrom; Lluís Puig

doi:10.20944/preprints202307.1499.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 21 July 2023 / Approved: 21 July 2023 / Online: 21 July 2023 (10:27:08 CEST)

Psoriasis is considered an immune-mediated disease involving the innate and adaptative immune system triggered by environmental risk factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent technological advances, specially genome and epigenome-wide studies, have allowed a more sensitive study of the genetic and epigenetic mechanisms, allowing an enhanced understanding of its physiopathology and facilitating the development of new drugs. In this review, we aim to summarize the current evidence on genetic and epigenetic mechanisms of psoriasis.

psoriasis; genetics; epigenomics

Medicine and Pharmacology, Dermatology

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Genetic and Epigenetic Mechanisms of Psoriasis

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