Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Just Keep Rolling? – An Encompassing Review towards Accelerated Vaccine Product Life Cycles

Janis Stiefel
* ORCID logo ,
Jeffrey Schloßhauer
‡ ,
Agnes Vosen
‡ ,
Sarah Kilz
‡ ,
Jan Zimmer
‡ ,
Sascha Balakin
‡ ORCID logo
‡
These authors contributed equally
Version 1 : Received: 19 July 2023 / Approved: 19 July 2023 / Online: 20 July 2023 (02:34:07 CEST)

A peer-reviewed article of this Preprint also exists.

Stiefel, J.; Zimmer, J.; Schloßhauer, J.L.; Vosen, A.; Kilz, S.; Balakin, S. Just Keep Rolling?—An Encompassing Review towards Accelerated Vaccine Product Life Cycles. Vaccines 2023, 11, 1287. Stiefel, J.; Zimmer, J.; Schloßhauer, J.L.; Vosen, A.; Kilz, S.; Balakin, S. Just Keep Rolling?—An Encompassing Review towards Accelerated Vaccine Product Life Cycles. Vaccines 2023, 11, 1287.

Abstract

In light of the recent pandemic, several COVID-19 vaccines were developed, tested and approved in a very short time, a process that otherwise takes many years. Above all, these efforts have also unmistakably revealed the capacity limits and potential for improvement in vaccine production. This review aims to emphasize recent approaches for targeted rapid adaptation and production of vaccines from an interdisciplinary multifaceted perspective. Using literature research, stakeholder analysis and a value proposition canvas, we reviewed technological innovations on the pharmacological level, formulation, validation and resilient vaccine production to supply bottlenecks and logistic networks. We identified four main drivers to accelerate the vaccine product life cycle: computerized candidate screening, modular production, digitized quality management and a resilient business model with corresponding transparent supply chains. In summary, the results presented here can serve as a guide and implementation tool for flexible, scalable vaccine production to respond swiftly to pandemic situations in the future.

Keywords

vaccine adaption; product life cycle; nanocarrier; mRNA vaccines; vaccine market; protein structure prediction; digital twin

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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