Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease – Pathophysiology and Translational Therapeutic Approaches

Michael Poledniczek
ORCID logo ,
Christoph Neumayer
ORCID logo ,
Christoph W. Kopp
,
Oliver Schlager
,
Thomas Gremmel
,
Alicja Jozkowicz
,
Michael E. Gschwandtner
,
Renate Koppensteiner
,
Patricia P. Wadowski
* ORCID logo
Version 1 : Received: 15 July 2023 / Approved: 17 July 2023 / Online: 17 July 2023 (05:31:19 CEST)

A peer-reviewed article of this Preprint also exists.

Poledniczek, M.; Neumayer, C.; Kopp, C.W.; Schlager, O.; Gremmel, T.; Jozkowicz, A.; Gschwandtner, M.E.; Koppensteiner, R.; Wadowski, P.P. Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches. Biomedicines 2023, 11, 2284. Poledniczek, M.; Neumayer, C.; Kopp, C.W.; Schlager, O.; Gremmel, T.; Jozkowicz, A.; Gschwandtner, M.E.; Koppensteiner, R.; Wadowski, P.P. Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease—Pathophysiology and Translational Therapeutic Approaches. Biomedicines 2023, 11, 2284.

Abstract

Inflammation has a critical role in the development and progression of atherosclerosis. On the molecular level, inflammatory pathways negatively impact endothelial barrier properties and thus tissue homeostasis. Conformational changes and destruction of the glycocalyx further promote proinflammatory pathways also contributing to procoagulability and a prothrombotic state. In addition, changes in the extracellular matrix composition lead to (peri-)vascular remodelling and alterations of the vessel wall, e.g., aneurysm formation. Moreover, progressive fibrosis leads to reduced tissue perfusion due to loss of functional capillaries. The present review aims at discussing molecular and clinical effects of inflammatory processes on the micro- and microvas-culature with a focus on peripheral artery disease.

Keywords

atherosclerosis; inflammation; peripheral artery disease; glycocalyx; endothelial dysfunction

Subject

Medicine and Pharmacology, Internal Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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