Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Paradigm of the EMT Process. Tissue-Specific Factors as a Potential Treatment Tool for Prostate Cancer Patients

Version 1 : Received: 14 July 2023 / Approved: 14 July 2023 / Online: 14 July 2023 (16:12:32 CEST)

How to cite: Parol-Kulczyk, M. E.; Grzanka, D. The Paradigm of the EMT Process. Tissue-Specific Factors as a Potential Treatment Tool for Prostate Cancer Patients. Preprints 2023, 2023071026. https://doi.org/10.20944/preprints202307.1026.v1 Parol-Kulczyk, M. E.; Grzanka, D. The Paradigm of the EMT Process. Tissue-Specific Factors as a Potential Treatment Tool for Prostate Cancer Patients. Preprints 2023, 2023071026. https://doi.org/10.20944/preprints202307.1026.v1

Abstract

Prostate cancer is the most occurred malignant disease in the male population in over one-half of the countries and still constitutes the fifth leading cause of death in 2020, worldwide. Metastatic prostate cancer is a lethal malignancy that mostly is terminated within several years through the patient's death. Researchers should focus on the phenomenon which is rigorously appertaining to metastatic cascade and operating as an initiator of metastases to provide the knowledge needed to solve the problem of diagnostics and treatment of advanced prostate cancer patients. The epithelial-mesenchymal transition is one such phenomenon. The current review is based mainly on three papers published in 2021, which describe the most important tissue-specific factors managing epithelial-mesenchymal transition and are discussed with scientific papers published in acknowledged journals. The effect of the current review is the specification of profiles of precise tissue factors predicting the progression of the prostate neoplasm to its metastatic stage in a new edition.

Keywords

epithelial-mesenchymal transition; prostate cancer; tissue biomarkers; microRNA; EMT-related proteins; metastasis

Subject

Medicine and Pharmacology, Pathology and Pathobiology

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