Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Novel, Functional Refined Olive Oil, Enhanced with Orange Peel Extract Modulates Postprandial LDL-Cholesterol Responses at Cardiometabolic Risk Individuals: A Pilot Randomized, Controlled, Cross-Over Nutritional Intervention

Olga Papagianni
ORCID logo ,
Chrysoula Kaloteraki
ORCID logo ,
Aikaterini Kandyliari
,
Panagiota Potsaki
,
Panorea Bousdouni
,
Kalliopi Almpounioti
ORCID logo ,
Camille Ouzaid
,
Anna-Kyriaki Mavrou
,
Vasiliki Panteli
,
Thomas Loukas
,
Athanasios Magkoutis
ORCID logo ,
Dimitrios Skalkos
ORCID logo ,
Haralabos C. Karantonis
ORCID logo ,
Antonios E. Koutelidakis
* ORCID logo
Version 1 : Received: 6 July 2023 / Approved: 7 July 2023 / Online: 7 July 2023 (03:55:50 CEST)

A peer-reviewed article of this Preprint also exists.

Papagianni, O.; Kaloteraki, C.; Kandyliari, A.; Potsaki, P.; Bousdouni, P.; Almpounioti, K.; Ouzaid, C.; Mavrou, A.-K.; Panteli, V.; Loukas, T.; Magkoutis, A.; Skalkos, D.; Karantonis, H.C.; Koutelidakis, A.E. A Novel Functional Refined Olive Oil, Enhanced with Orange Peel Extract, Modulates Postprandial LDL-Cholesterol Responses in Individuals at Cardiometabolic Risk: A Pilot Randomized, Controlled, Cross-Over Nutritional Intervention. Appl. Sci. 2023, 13, 8574. Papagianni, O.; Kaloteraki, C.; Kandyliari, A.; Potsaki, P.; Bousdouni, P.; Almpounioti, K.; Ouzaid, C.; Mavrou, A.-K.; Panteli, V.; Loukas, T.; Magkoutis, A.; Skalkos, D.; Karantonis, H.C.; Koutelidakis, A.E. A Novel Functional Refined Olive Oil, Enhanced with Orange Peel Extract, Modulates Postprandial LDL-Cholesterol Responses in Individuals at Cardiometabolic Risk: A Pilot Randomized, Controlled, Cross-Over Nutritional Intervention. Appl. Sci. 2023, 13, 8574.

Abstract

Olive oil, as the main source of polyphenols in the Mediterranean diet pattern, is mentioned to show remarkable postprandial bioactivity, contributing to the reduction of cardiometabolic risk factors. In recent years, the consumption of refined olive oil, instead of other olive oil classes, led to a reduced intake of polyphenols from the usual diet. This controlled, human nutritional intervention inves-tigated whether the enhancement of refined olive oil with orange peel extract may modulate postprandial lipemia, glycemia and oxidative stress, in individuals at cardiometabolic risk. In a cross-over framework, 21 participants aged 30-65 years, who met the eligibility criteria, received a fat and carbohydrated meal of mashed potatoes, homogenized with refined olive oil (50 mL) or the functional olive oil, enhanced with 10% orange peel extract, intervening a washout week. Blood draws were performed in fasting, 30min, 1.5h and 3h after the meal intake. Plasma lipids, glucose, uric acid and total plasma antioxidant capacity according to FRAP method, were measured at each timepoint. A significant reduction of LDL-cholesterol was observed, 1.5 h and 3 h after the func-tional meal intake, compared to non-significant changes after the control meal (p <0.05). No other statistically significant interactions were detected to the remaining biomarkers (p> 0.05). Further investigation is needed for safer conclusions about the postprandial modulation of cardiometabolic risk factors, by the functional olive oil, enhanced with orange peel extract.

Keywords

postprandial bioactivity; polyphenols; functional olive oil; orange peel extract; cardiometabolic risk

Subject

Biology and Life Sciences, Food Science and Technology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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