Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Long Covid: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog

Version 1 : Received: 29 June 2023 / Approved: 30 June 2023 / Online: 4 July 2023 (03:10:58 CEST)
Version 2 : Received: 12 August 2023 / Approved: 14 August 2023 / Online: 15 August 2023 (05:03:11 CEST)

A peer-reviewed article of this Preprint also exists.

Menichetti, F. The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post-COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog. J. Clin. Med. 2023, 12, 5478. Menichetti, F. The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post-COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog. J. Clin. Med. 2023, 12, 5478.

Abstract

Long Covid is a heterogeneous clinical condition in which Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and brain fog stand out among the different clinical symptoms and syndromes. The cerebral metabolic alterations and neuroendocrine disorders seem to constitute an important part of Long Covid. Given the substantial lack of drugs and effective therapeutic strategies, hypothalamic phospholipid liposomes which have been on the market for several years as adjuvant therapy of cerebral metabolic alterations resulting from neuroendocrine disorders, can be taken into consideration in an overall therapeutic strategy that aims to control the Long Covid associated symptoms and syndromes. Their pharmacological mechanisms and clinical effects strongly support their usefulness in Long Covid. Our initial clinical experience corroborates this rationale. Further research is imperative in order to obtain robust clinical evidence.

Keywords

Long Covid; Covid-19; post-COVID syndrome; neuroendocrine disorders; chronic fatigue; brain fog; phospholipids; phospholipid liposome; phosphatidylserine

Subject

Medicine and Pharmacology, Internal Medicine

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