Li, S.; Shen, Y.; Dong, C.; Yin, S.; Zhou, D.; Zhou, A. The Molecular and Immune Microenvironmental Landscape of Brain Metastases: Implications for Novel Treatment Options. Preprints2023, 2023061438. https://doi.org/10.20944/preprints202306.1438.v1
APA Style
Li, S., Shen, Y., Dong, C., Yin, S., Zhou, D., & Zhou, A. (2023). The Molecular and Immune Microenvironmental Landscape of Brain Metastases: Implications for Novel Treatment Options. Preprints. https://doi.org/10.20944/preprints202306.1438.v1
Chicago/Turabian Style
Li, S., Dong Zhou and Aidong Zhou. 2023 "The Molecular and Immune Microenvironmental Landscape of Brain Metastases: Implications for Novel Treatment Options" Preprints. https://doi.org/10.20944/preprints202306.1438.v1
Abstract
Brain metastasis (BrM), involving the spread of cells from a primary tumor through the blood circulation system to the brain microvasculature, eventually progresses despite multiple treatments and remains a substantial contributor to major mortality in patients with advanced- stage cancer. Molecular signatures and immune cellular components of the tumor microenvironment (TME) are emerging as essential regulators involved in establishing an organ-specific metastasis (colonization) and therapeutic response. A comprehensive understanding of detailed characterization and the immune landscape in context of process of BrM formation will greatly expand the horizon of treatments available to target these deadly diseases. In this review, we provide a comprehensive picture of the complex interactions between tumor cells and immune cellular components participated in the BrM process. Based on this knowledge, we will discuss opportunities and challenges for therapeutic strategies against BrM.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
