Watanabe, T.; Hasuike, A.; Wakuda, S.; Kogure, K.; Min, S.; Watanabe, N.; Sakai, R.; Chaurasia, A.; Arai, Y.; Sato, S. Resorbable Bilayer Membrane Made of L-Lactide-ε-Caprolactone in Guided Bone Regeneration: An in Vivo Experimental Study. International Journal of Implant Dentistry 2024, 10, doi:10.1186/s40729-024-00520-7.
Watanabe, T.; Hasuike, A.; Wakuda, S.; Kogure, K.; Min, S.; Watanabe, N.; Sakai, R.; Chaurasia, A.; Arai, Y.; Sato, S. Resorbable Bilayer Membrane Made of L-Lactide-ε-Caprolactone in Guided Bone Regeneration: An in Vivo Experimental Study. International Journal of Implant Dentistry 2024, 10, doi:10.1186/s40729-024-00520-7.
Watanabe, T.; Hasuike, A.; Wakuda, S.; Kogure, K.; Min, S.; Watanabe, N.; Sakai, R.; Chaurasia, A.; Arai, Y.; Sato, S. Resorbable Bilayer Membrane Made of L-Lactide-ε-Caprolactone in Guided Bone Regeneration: An in Vivo Experimental Study. International Journal of Implant Dentistry 2024, 10, doi:10.1186/s40729-024-00520-7.
Watanabe, T.; Hasuike, A.; Wakuda, S.; Kogure, K.; Min, S.; Watanabe, N.; Sakai, R.; Chaurasia, A.; Arai, Y.; Sato, S. Resorbable Bilayer Membrane Made of L-Lactide-ε-Caprolactone in Guided Bone Regeneration: An in Vivo Experimental Study. International Journal of Implant Dentistry 2024, 10, doi:10.1186/s40729-024-00520-7.
Abstract
Insufficient oral ridge tissue presents a challenge in the treatment of dental implants. One method to enhance alveolar crest dimensions is guided bone regeneration (GBR); however, existing membranes have certain limitations. To address this issue, we aimed to compare the effectiveness of a resorbable bilayer membrane composed of poly(l-lactic acid) and poly(-caprolactone) (PLACL)with that of a collagen membrane(COL) in a rat GBR model. The rat calvaria was used as an experimental model by placing a plastic cylinder. Forty male Fisher rats underwent surgery, and micro-computed tomography and histomorphometric analyses were performed to assess bone regeneration. The results showed that bone regeneration was similar across all the groups. However, after 24 weeks, the PLACL membrane demonstrated significant resilience, occasional partial degradation, and intermittent air bubble formation. This extended preservation of the barrier effect has great potential to facilitate optimal bone regeneration. In conclusion, this study shows that the PLACL membrane is a promising alternative to GBR. By providing a durable barrier and supporting bone regeneration over an extended period, this resorbable bilayer membrane may address the limitations of the current membranes. Further studies and clinical trials are warranted to validate the efficacy and safety of this drug in humans.
Keywords
Guided Bone Regeneration; dental implant; PLACL; resorbable bilayer membrane
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
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