Version 1
: Received: 7 June 2023 / Approved: 7 June 2023 / Online: 7 June 2023 (07:17:52 CEST)
Version 2
: Received: 11 June 2023 / Approved: 12 June 2023 / Online: 12 June 2023 (05:29:21 CEST)
Li, J.; Yan, Y.; Chen, Y.; Fang, Q.; Hussain, M.I.; Wang, L.-N. Flexible Curcumin-Loaded Zn-MOF Hydrogel for Long-Term Drug Release and Antibacterial Activities. Int. J. Mol. Sci.2023, 24, 11439.
Li, J.; Yan, Y.; Chen, Y.; Fang, Q.; Hussain, M.I.; Wang, L.-N. Flexible Curcumin-Loaded Zn-MOF Hydrogel for Long-Term Drug Release and Antibacterial Activities. Int. J. Mol. Sci. 2023, 24, 11439.
Li, J.; Yan, Y.; Chen, Y.; Fang, Q.; Hussain, M.I.; Wang, L.-N. Flexible Curcumin-Loaded Zn-MOF Hydrogel for Long-Term Drug Release and Antibacterial Activities. Int. J. Mol. Sci.2023, 24, 11439.
Li, J.; Yan, Y.; Chen, Y.; Fang, Q.; Hussain, M.I.; Wang, L.-N. Flexible Curcumin-Loaded Zn-MOF Hydrogel for Long-Term Drug Release and Antibacterial Activities. Int. J. Mol. Sci. 2023, 24, 11439.
Abstract
Management of chronic inflammation and wounds has always been a key issue in the pharmaceutical and healthcare sector. Curcumin (CCM) is an active ingredient extracted from turmeric rhizomes that has antioxidant, anti-inflammatory, and antibacterial activities, thus showing significant effectiveness toward wound healing. However, its shortcomings such as poor water solubility, poor chemical stability and fast metabolic rate limit its bioavailability and long-term use. In this context, hydrogels appear to be a versatile matrix for carrying and stabilizing drugs due to the biomimetic structure, soft porous microarchitecture, and pleasant biomechanical properties. The drug loading/releasing efficiencies can also be controlled by use of highly crystalline and porous metal organic frameworks (MOFs). Here, a flexible hydrogel composed of sodium alginate (SA) matrix and CCM-loaded MOFs was constructed for long-term drug release and antibacterial activity. The morphology and physicochemical properties of composite hydrogels were analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), ultraviolet visible spectroscopy (UV-Vis), Raman spectroscopy and mechanical property tests. The results showed that the composite hydrogel was highly twistable and bendable to mechanically comply with human skin. The as-prepared hydrogel could capture efficient CCM for slow drug release as well as effective killing of bacteria. Therefore, such composite hydrogel is expected to provide a new management system for chronic wound dressings.
Keywords
Curcumin; MOF; Sodium Alginate Hydrogel; Drug Release; Antibacterial Activity
Subject
Chemistry and Materials Science, Nanotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
