Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Behind Mouse Eyes: The Function and Control of Eye Movements in Mice

Version 1 : Received: 4 June 2023 / Approved: 6 June 2023 / Online: 6 June 2023 (02:44:55 CEST)

A peer-reviewed article of this Preprint also exists.

Ambrad Giovannetti, E.; Rancz, E. Behind Mouse Eyes: The Function and Control of Eye Movements in Mice. Neuroscience & Biobehavioral Reviews 2024, 161, 105671, doi:10.1016/j.neubiorev.2024.105671. Ambrad Giovannetti, E.; Rancz, E. Behind Mouse Eyes: The Function and Control of Eye Movements in Mice. Neuroscience & Biobehavioral Reviews 2024, 161, 105671, doi:10.1016/j.neubiorev.2024.105671.

Abstract

The mouse visual system recently became the most popular model to study the cellular and circuit mechanisms of sensory processing. However, the importance of eye movements in mice only started to be appreciated recently. Eye movements provide a basis for active sensing and deliver insights into various brain functions and dysfunctions. A plethora of knowledge on the central control of eye movements and their role in perception and behaviour arose from work on primates. However, an overview of the known eye movement types in mice and a comparison to primates is missing.Here, we review the eye movement types described to date in mice and compare them to those observed in primates. We discuss the central neuronal mechanisms for their generation and control. Furthermore, we review the mounting literature on eye movements in mice during head-fixed and freely moving behaviours. Finally, we highlight gaps in our understanding and suggest future directions for research.

Keywords

eye movements; visual system; mouse vision

Subject

Biology and Life Sciences, Neuroscience and Neurology

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