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Centella asiatica Lowers Body Fat Accumulation via Regulating Cholesterol Homeostasis- and Lipid Metabolism-Related Genes in Mice with High-Fat, High-Sugar Diet-Induced Obesity
Chang, Y.B.; Ahn, Y.; Seo, D.; Bae, S.; Suh, H.J.; Hong, Y.H.; Jung, E.Y. Centella Asiatica Lowers Body Fat Accumulation via Regulating Cholesterol Homeostasis- and Lipid Metabolism-Related Genes in Mice with High-Fat, High-Sugar Diet-Induced Obesity. Applied Biological Chemistry 2023, 66, doi:10.1186/s13765-023-00846-7.
Chang, Y.B.; Ahn, Y.; Seo, D.; Bae, S.; Suh, H.J.; Hong, Y.H.; Jung, E.Y. Centella Asiatica Lowers Body Fat Accumulation via Regulating Cholesterol Homeostasis- and Lipid Metabolism-Related Genes in Mice with High-Fat, High-Sugar Diet-Induced Obesity. Applied Biological Chemistry 2023, 66, doi:10.1186/s13765-023-00846-7.
Chang, Y.B.; Ahn, Y.; Seo, D.; Bae, S.; Suh, H.J.; Hong, Y.H.; Jung, E.Y. Centella Asiatica Lowers Body Fat Accumulation via Regulating Cholesterol Homeostasis- and Lipid Metabolism-Related Genes in Mice with High-Fat, High-Sugar Diet-Induced Obesity. Applied Biological Chemistry 2023, 66, doi:10.1186/s13765-023-00846-7.
Chang, Y.B.; Ahn, Y.; Seo, D.; Bae, S.; Suh, H.J.; Hong, Y.H.; Jung, E.Y. Centella Asiatica Lowers Body Fat Accumulation via Regulating Cholesterol Homeostasis- and Lipid Metabolism-Related Genes in Mice with High-Fat, High-Sugar Diet-Induced Obesity. Applied Biological Chemistry 2023, 66, doi:10.1186/s13765-023-00846-7.
Abstract
To understand the mechanisms involved in the anti-obesity effects Centella asi-atica (CA), we examined body weight, serum levels, white adipose tissue (WAT) weight, histological analysis, and the expression of cholesterol homeostasis- and lipid metabolism-related genes in mice with high-fat, high-sugar diet (HFHSD)-induced obesity that were orally treated with CA for 12 weeks. Eight-week-old, male C57BL/6J mice were assigned to the following four groups (eight mice/group): NOR, normal diet; Control, HFHSD; CA-L, HFHSD+CA 300 mg/kg; CA-H, HFHSD+CA 600 mg/kg. CA treatment signifi-cantly attenuated HFHSD-induced increase in body weight gain, serum glucose, serum triacylglycerol, and WAT weight (p < 0.05). Compared to that in Control group, adipocyte diameter and macrovesicular area of epididymal WAT signif-icantly decreased with CA treatment (p < 0.05). The mRNA expression levels of peroxisome proliferator-activated receptor gamma (PPARγ), fatty acid synthase (FAS), cluster of differentiation 36 (CD36), 3- hydroxyl-3-methylglutaryl CoA reductase (HMGCR), and stearoyl CoA desaturase 1 (SCD 1) were significantly downregulated in the CA-H group compared to the Control group (p < 0.05). CA exerts anti-obesity effects by lowering body fat accumulation via regulat-ing gene expression in the liver and thus, is a potential lipid-lowering agent.
Keywords
Centella asiatica; body weight; obesity; adipocyte
Subject
Public Health and Healthcare, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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