Schupfer, E.; Ooi, S.L.; Jeffries, T.C.; Wang, S.; Micalos, P.S.; Pak, S.C. Changes in the Human Gut Microbiome during Dietary Supplementation with Modified Rice Bran Arabinoxylan Compound. Molecules2023, 28, 5400.
Schupfer, E.; Ooi, S.L.; Jeffries, T.C.; Wang, S.; Micalos, P.S.; Pak, S.C. Changes in the Human Gut Microbiome during Dietary Supplementation with Modified Rice Bran Arabinoxylan Compound. Molecules 2023, 28, 5400.
Schupfer, E.; Ooi, S.L.; Jeffries, T.C.; Wang, S.; Micalos, P.S.; Pak, S.C. Changes in the Human Gut Microbiome during Dietary Supplementation with Modified Rice Bran Arabinoxylan Compound. Molecules2023, 28, 5400.
Schupfer, E.; Ooi, S.L.; Jeffries, T.C.; Wang, S.; Micalos, P.S.; Pak, S.C. Changes in the Human Gut Microbiome during Dietary Supplementation with Modified Rice Bran Arabinoxylan Compound. Molecules 2023, 28, 5400.
Abstract
This study investigated the effects of modified rice bran arabinoxylan compound (RBAC) as a dietary supplement on the gut microbiota of healthy adults. Ten volunteers supplemented their diet with 1g of RBAC for six weeks and 3g of RBAC for another six weeks, with a three-week washout period. Faecal samples were collected every 3 weeks over 21 weeks. Microbiota from faecal samples were profiled using 16S rRNA sequencing. Assessment of alpha and beta microbiota diversity was performed using the QIIME2 platform. The results revealed that alpha and beta diversity were not associated with the experimental phase, interventional period, RBAC dosage, or time. However, statistical significance of participant was detected in alpha (p<0.002) and beta (weighted unifrac, p=0.001) diversity. Explanatory factors including age and diet were significantly associated with alpha (p<0.05) and beta (p<0.01) diversity. The individual beta diversity of six participants significantly changed (p<0.05) during the interventional period. Seven participants showed statistically significant taxonomic changes (ANCOM W≥5). These results classified four participants as responders to RBAC supplementation, with a further two participants likely responders. In conclusion, the gut microbiome is highly individualised and modulated by RBAC as a dietary supplement, dependent on lifestyle and dietary intake
Biology and Life Sciences, Biology and Biotechnology
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