Jaroszyński, A.; Wójtowicz, R.; Piasek, E.; Dąbrowski, W. Is HSP-27 an Emerging Marker of Good Prognosis in Septic Shock? A Pilot Study. Medical Studies 2024, 40, 17–21, doi:10.5114/ms.2024.137591.
Jaroszyński, A.; Wójtowicz, R.; Piasek, E.; Dąbrowski, W. Is HSP-27 an Emerging Marker of Good Prognosis in Septic Shock? A Pilot Study. Medical Studies 2024, 40, 17–21, doi:10.5114/ms.2024.137591.
Jaroszyński, A.; Wójtowicz, R.; Piasek, E.; Dąbrowski, W. Is HSP-27 an Emerging Marker of Good Prognosis in Septic Shock? A Pilot Study. Medical Studies 2024, 40, 17–21, doi:10.5114/ms.2024.137591.
Jaroszyński, A.; Wójtowicz, R.; Piasek, E.; Dąbrowski, W. Is HSP-27 an Emerging Marker of Good Prognosis in Septic Shock? A Pilot Study. Medical Studies 2024, 40, 17–21, doi:10.5114/ms.2024.137591.
Abstract
Is HSP-27 an emerging marker of good prognosis in septic shock patients – a pilot study
Objective
To estimate the value of serum changes of C-reactive protein, procalcitonin, presepsin, heat shock protein 27 (HSP27) and neutrophil to lymphocyte ratio in assessing the prognosis in patients with septic shock (SS) treated in intensive care unit.
Methods
The SS was diagnosed and treated in accordance with the guidelines of the Surviving Sepsis Campaign. 37 selected adult patients with SS were included. Serum concentrations of biomarkers were measured at admission and daily for 4 consecutive days (time points T0,T1, T2, T3 and T4 respectively). The mortality rate was determined 28 days after admission. Patients were divided into survivor and non-survivor groups according to their mortality. The differences between the levels of biomarkers at the T0 and T4 time points were analyzed.
Results
The mean value of the SOFA score on admission was 11.7 ± 2.7, and the APACHE II scale 29.9 ± 6.85. Nine patients died. Univariate logistic analysis revealed that changes between T0 and T4 time points of presepsin, procalcytonin, and HSP27 were associated with prognosis. A multivariate Cox analysis showed that an increase in HSP27 on T4 was the only independent predictor of good prognosis in SS patients. The area under the receiver operating characteristics curve for HSP27 was 0.785. Kaplan–Meier analysis showed that the mortality was lower (p=0.014) in patients who had an increase in HSP27 on T4 compared to those whose serum HSP27 did not increase on T4.
Conclusions
The increase of HSP27 level on the 4th day predicts favorable outcome in SS patients.
Keywords
mortality; sepsis; shock; heat shock protein 27
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
