Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Zn-Doped Calcium Magnesium Phosphate Bone Cements Based on Struvite and Their Antibacterial Properties

Version 1 : Received: 29 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (09:45:06 CEST)

A peer-reviewed article of this Preprint also exists.

Krokhicheva, P.A.; Goldberg, M.A.; Fomin, A.S.; Khayrutdinova, D.R.; Antonova, O.S.; Baikin, A.S.; Leonov, A.V.; Merzlyak, E.M.; Mikheev, I.V.; Kirsanova, V.A.; Sviridova, I.K.; Akhmedova, S.A.; Sergeeva, N.S.; Barinov, S.M.; Komlev, V.S. Zn-Doped Calcium Magnesium Phosphate Bone Cement Based on Struvite and Its Antibacterial Properties. Materials 2023, 16, 4824. Krokhicheva, P.A.; Goldberg, M.A.; Fomin, A.S.; Khayrutdinova, D.R.; Antonova, O.S.; Baikin, A.S.; Leonov, A.V.; Merzlyak, E.M.; Mikheev, I.V.; Kirsanova, V.A.; Sviridova, I.K.; Akhmedova, S.A.; Sergeeva, N.S.; Barinov, S.M.; Komlev, V.S. Zn-Doped Calcium Magnesium Phosphate Bone Cement Based on Struvite and Its Antibacterial Properties. Materials 2023, 16, 4824.

Abstract

The development of magnesium calcium phosphate bone cements (MCPCs) have garnered big attention. MCPCs are bioactive and biodegradable and have appropriate mechanical and antimicrobial properties for use in reconstructive surgery. In this study, the cement powders based on a (Ca + Mg)/P = 2 system doped with Zn2+ at 0.5 and 1.0 wt.% were obtained and investigated. After the mixing with a cement liquid, structural and phase composition, morphology, chemical structure, setting time, compressive strength, degradation behavior, solubility, antibacterial activities, and in vitro behaviour of the cement materials were examined. A high compressive strength of 48 ± 5 MPa (mean ± SD) was achieved for the cement made from Zn2+ 1.0-wt.%-substituted powders. The Zn2+ introduction led to antibacterial activity against Staphylococcus aureus and Escherichia coli strains, with an inhibition zone diameter up to 8 mm. Biological assays confirmed that the developed cements are cytocompatible and promising as a potential bone substitute in reconstructive surgery.

Keywords

calcium phosphate; magnesium phosphate; bone cement; antibacterial properties; ; cytocompatibility

Subject

Chemistry and Materials Science, Biomaterials

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