Kubiliene, A.; Munius, E.; Songailaite, G.; Kokyte, I.; Baranauskaite, J.; Liekis, A.; Sadauskiene, I. A Comparative Evaluation of Antioxidant Activity of Extract and Essential Oil of Origanum onites L. In Vivo. Molecules2023, 28, 5302.
Kubiliene, A.; Munius, E.; Songailaite, G.; Kokyte, I.; Baranauskaite, J.; Liekis, A.; Sadauskiene, I. A Comparative Evaluation of Antioxidant Activity of Extract and Essential Oil of Origanum onites L. In Vivo. Molecules 2023, 28, 5302.
Kubiliene, A.; Munius, E.; Songailaite, G.; Kokyte, I.; Baranauskaite, J.; Liekis, A.; Sadauskiene, I. A Comparative Evaluation of Antioxidant Activity of Extract and Essential Oil of Origanum onites L. In Vivo. Molecules2023, 28, 5302.
Kubiliene, A.; Munius, E.; Songailaite, G.; Kokyte, I.; Baranauskaite, J.; Liekis, A.; Sadauskiene, I. A Comparative Evaluation of Antioxidant Activity of Extract and Essential Oil of Origanum onites L. In Vivo. Molecules 2023, 28, 5302.
Abstract
In the present study the effects of Origanum onites L. extract and essential oil of O. onites L. on the antioxidant status of the liver and brain of mice were investigated. Due to certain disadvantages of essential oils, such as poor solubility, high volatility, sensitivity to UV light and heat, formulation of liposomes with Oregano essentials (OE) was optimized and used in this study. The results demonstrated that the best composition of the lipid carriers and Oregano essentials were conducted in terms of the PDI, mean particle size and EE. The LE4 formulation contained Lipoid S100 of 45 mg, Lipoid S75 of 45 mg and 90 mg of EO. The administration of O. onites L. extract to mice for 21 days significantly decreased glutathione (GSH) level in the liver and brain of mouse as well as malondialdehyde (MDA) concentration in the liver. In the brain of mice MDA level significantly increased after this extract consumption. Whereas liposomes with OE significantly decreased GSH concentration in mouse brain and MDA concentration in mouse liver but increased (p>0.05) GSH level in liver and MDA concentration in brain of mice compared with the control group. It was investigated that both, O. onites L. extract as well as liposomes with OE of this plant material make changes in the antioxidant status in the liver and brain of mice.
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