PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
The Frequency and Patterns of Age- and Gender-Specific Neurogastroenterological Consequences in Saudi Millennial Women Imply Potential Post-COIVD-19 Dysbiosis
Version 1
: Received: 19 May 2023 / Approved: 23 May 2023 / Online: 23 May 2023 (02:37:42 CEST)
How to cite:
Alsolami, A.; Melibari, Z.A.; Alharbi, Y.H.; Almutlag, A.A.; Aboras, R.; Alreshidi, F.S.; Fathuddin, A.; Alshammari, F.; Alrashid, F.; Osman, S.S.; Said, K.B. The Frequency and Patterns of Age- and Gender-Specific Neurogastroenterological Consequences in Saudi Millennial Women Imply Potential Post-COIVD-19 Dysbiosis. Preprints2023, 2023051535. https://doi.org/10.20944/preprints202305.1535.v1
Alsolami, A.; Melibari, Z.A.; Alharbi, Y.H.; Almutlag, A.A.; Aboras, R.; Alreshidi, F.S.; Fathuddin, A.; Alshammari, F.; Alrashid, F.; Osman, S.S.; Said, K.B. The Frequency and Patterns of Age- and Gender-Specific Neurogastroenterological Consequences in Saudi Millennial Women Imply Potential Post-COIVD-19 Dysbiosis. Preprints 2023, 2023051535. https://doi.org/10.20944/preprints202305.1535.v1
Alsolami, A.; Melibari, Z.A.; Alharbi, Y.H.; Almutlag, A.A.; Aboras, R.; Alreshidi, F.S.; Fathuddin, A.; Alshammari, F.; Alrashid, F.; Osman, S.S.; Said, K.B. The Frequency and Patterns of Age- and Gender-Specific Neurogastroenterological Consequences in Saudi Millennial Women Imply Potential Post-COIVD-19 Dysbiosis. Preprints2023, 2023051535. https://doi.org/10.20944/preprints202305.1535.v1
APA Style
Alsolami, A., Melibari, Z.A., Alharbi, Y.H., Almutlag, A.A., Aboras, R., Alreshidi, F.S., Fathuddin, A., Alshammari, F., Alrashid, F., Osman, S.S., & Said, K.B. (2023). The Frequency and Patterns of Age- and Gender-Specific Neurogastroenterological Consequences in Saudi Millennial Women Imply Potential Post-COIVD-19 Dysbiosis. Preprints. https://doi.org/10.20944/preprints202305.1535.v1
Chicago/Turabian Style
Alsolami, A., Sara S. Osman and Kamaleldin B. Said. 2023 "The Frequency and Patterns of Age- and Gender-Specific Neurogastroenterological Consequences in Saudi Millennial Women Imply Potential Post-COIVD-19 Dysbiosis" Preprints. https://doi.org/10.20944/preprints202305.1535.v1
Abstract
Abstract: Gastroesophageal reflux disease (GERD), the inflammatory bowel disease (IBD), and mental health issues are significant public health concerns in globally. Although rising peaks observed post-COVID-19, there is a sever paucity in high quality data. Using descriptive analysis, we identified the frequency and associations of age- and gender, sport, genetic, and psychiatric consequences in the coexistence of GERD and IBD in 2067 participants 18 to >60 years with mean age of 26.8 ± 12.9 years. Most were 18 -29 years old (66%, n=1364) of which majority were young Saudi females (72.4%, n=1496). Estimated 1099 (53.2%) were students, 428 (20.7%) were unemployed, and 540 (26.1%) were. The majority were Saudis (94.7%, n= 1957). Psychological syndromes anxiety (60.7%), stress (60.7%), and depression (60.6%) were most frequent; whereas, IBD (48.7%) and GERD (36.3%), respectively were the second and third. In 51 % respondents depression, anxiety, and stress occurred first while in 33.9%, and 24.3% IBD and GERD, respectively, were the first signs. In most respondents (59.2%, n=1178), these signs first appeared recently and 33.6% (n=669) reported occurrence during adult life, and only in 7.2% (n=144) the signs noticed during childhood (7.2%, n=144)). Aggravating factors were 32.9% (n=681) genetic and other factors of which 476 (69.9%) inherited IBD while 215(31.6%) and 175 ((25.7), respectively, inherited psychological (depression, anxiety, and stress) and GERD. However, only 18.3% sought treatment (n=378) and only 66 (3.2%) had colectomy or a colostomy bag. Little over half of the studied population (58.1%, n=1201) were active in outdoor. GERD or IBS and psychological factors (anxiety, depression, and stress), were significantly associated with age (P value =.001).; GERD with old age, IBD with mid-age 40-49 years, and psychological disorders among younger ages. Thus, while mental health issues predispose young millennial women to neurogastroenterological disorders, the IBD and GERD initiate psychological problems in old and mid-ages, respectively. Intriguingly, despite the significantly mosaic global genetic population structures, their lifestyles, and nutritional habits, the pattern of these disorders remains similar. Thus, this is potentially consistent with notion that the gut nerve cells are conserved and that the changes in gut dysbiosis of gut microbiome signatures are responsible. These findings have significant clinical implications in the patient treatment strategies and tailored educational and awareness programs in lifestyle medicine. Future microbiome studies would reveal more insight into the mechanisms of disorders.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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