Adamczyk, M.; Bartosińska, J.; Raczkiewicz, D.; Michalak-Stoma, A.; Krasowska, D. The Impact of Biologic Treatment on PD-1/PD-L1 Pathway Disturbances in Psoriasis. J. Clin. Med.2023, 12, 4179.
Adamczyk, M.; Bartosińska, J.; Raczkiewicz, D.; Michalak-Stoma, A.; Krasowska, D. The Impact of Biologic Treatment on PD-1/PD-L1 Pathway Disturbances in Psoriasis. J. Clin. Med. 2023, 12, 4179.
Adamczyk, M.; Bartosińska, J.; Raczkiewicz, D.; Michalak-Stoma, A.; Krasowska, D. The Impact of Biologic Treatment on PD-1/PD-L1 Pathway Disturbances in Psoriasis. J. Clin. Med.2023, 12, 4179.
Adamczyk, M.; Bartosińska, J.; Raczkiewicz, D.; Michalak-Stoma, A.; Krasowska, D. The Impact of Biologic Treatment on PD-1/PD-L1 Pathway Disturbances in Psoriasis. J. Clin. Med. 2023, 12, 4179.
Abstract
Programmed-death-1 (PD-1) receptor plays a major physiological role in maintainance of im-mune tolerance, and, by interaction with its ligands (PD-L1 and PD-L2), prevents the develop-ment of multiple immune-mediated diseases. There is growing evidence of an important role of PD-1/PD-L1 pathway in pathogenesis of psoriasis. 84 subjects with psoriasis were included into the study, together with 29 healthy subjects as a control group. 28 of psoriatic patients were treated with biologice therapy (TNF-alpha, interleukin (IL)-12/23 or IL-17 inhibitors). Amounts of PD1 and PD-L1 positive T-cells in peripheral blood were evaluated using flow cytometry. Significantly lower levels of peripheral blood mononuclear cells (PBMCs) with the expression of PD-1 and PD-L1 were found in psoriatic patients when compared to healthy individuals, i.e. CD3/PD1, CD3/PDL1, CD4/PD1, CD4/PDL1, CD8/PDL1, CD19/PD1, CD19/PDL1 positive cells. Biologic treatment resulted in elevation of CD3/PDL1, CD8/PDL1 and decrease of CD8/PD1 posi-tive PBMCs. Our results confirm previous observations of disrupted PD-1/PD-L1 pathway in psoriasis, and that this disturbances may play an important role in development of the disease. Biologic drugs may reverse several abnormalities observed within this pathway, which may ex-plain their excellent efficacy in the treatment of psoriasis. Further research should be conducted to fully explain the results obtained.
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