Wu, Q.; Zhang, D.; Sun, S.; Liu, C.; Wang, C. An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol. Catalysts2023, 13, 1002.
Wu, Q.; Zhang, D.; Sun, S.; Liu, C.; Wang, C. An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol. Catalysts 2023, 13, 1002.
Wu, Q.; Zhang, D.; Sun, S.; Liu, C.; Wang, C. An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol. Catalysts2023, 13, 1002.
Wu, Q.; Zhang, D.; Sun, S.; Liu, C.; Wang, C. An Efficient and Mild Method for the Alkylation of p-Cresol with tert-Butyl Alcohol. Catalysts 2023, 13, 1002.
Abstract
The synthesis 2-tert-butyl-4-methylphenol is of great significance because of its widely application in industry, and the development of highly efficient catalyst is necessary to the alkylation of p-cresol and tert-butyl alcohol. Here, an efficient and mild method was established, caprolactam was chosen as hydrogen-bonding acceptor, p-toluenesulfonic acid was employed as hydrogen-bonding donor, and deep eutectic solvent (DES) was prepared to catalyze the alkylation reaction. The structure of the DES catalyst was characterized by 1H NMR spectra, thermogravimetric analysis and fourier transform infrared spectra (FT-IR). In addition, response surface design based on Box-Behnken method was employed to optimize the alkylation reaction process parameters, the study of reaction kinetics was also carried out subsequently. The recycle performance of the catalyst was evaluated by recovery experiments, and a good result was obtained. Comparing with the literature reported, we here provide a mild method to the synthesis of 2-tert-butyl-4-methylphenol.
Keywords
Alkylation reaction; deep eutectic solvent; mild; response surface methodology
Subject
Chemistry and Materials Science, Chemical Engineering
Copyright:
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