Li, Y.-J.; Wang, X.-L.; Shi, L.-Y.; Wang, Z.-Y.; Zhao, Z.-A.; Ge, S.-C.; Hu, B. DUSP2 Deletion Inhibits Macrophage Migration by Inhibiting ERK Activation in Zebrafish. Fishes2023, 8, 310.
Li, Y.-J.; Wang, X.-L.; Shi, L.-Y.; Wang, Z.-Y.; Zhao, Z.-A.; Ge, S.-C.; Hu, B. DUSP2 Deletion Inhibits Macrophage Migration by Inhibiting ERK Activation in Zebrafish. Fishes 2023, 8, 310.
Li, Y.-J.; Wang, X.-L.; Shi, L.-Y.; Wang, Z.-Y.; Zhao, Z.-A.; Ge, S.-C.; Hu, B. DUSP2 Deletion Inhibits Macrophage Migration by Inhibiting ERK Activation in Zebrafish. Fishes2023, 8, 310.
Li, Y.-J.; Wang, X.-L.; Shi, L.-Y.; Wang, Z.-Y.; Zhao, Z.-A.; Ge, S.-C.; Hu, B. DUSP2 Deletion Inhibits Macrophage Migration by Inhibiting ERK Activation in Zebrafish. Fishes 2023, 8, 310.
Abstract
Dual specificity phosphatase 2 (DUSP2) regulates the activation of members in the mitogen-activated protein kinase (MAPK) family, which is involved in a variety of cellular processes like cell proliferation, differentiation, apoptosis and migration. DUSP2 also regulates the expression of inflammatory mediators in macrophages, however, it remains unknown whether DUSP2 participates in macrophage migration. Here, using the tail fin injury model in zebrafish larvae, we found that deletion of DUSP2 inhibited expression of pro-inflammatory cytokines and macrophage chemokines. Moreover, live imaging results showed that migration of macrophages to the injury site was inhibited after DUSP2 deletion. This inhibitory effect was mediated through reduced activation of extracellular regulated protein kinases (ERK) in DUSP2 knockout zebrafish.
Keywords
Zebrafish; Macrophages; Migration; DUSP2; ERK
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
