P2x7 Receptor and Extracellular Vesicle Release

Maria Teresa Golia; Martina Gabrielli; Claudia Verderio

doi:10.20944/preprints202305.0050.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 30 April 2023 / Approved: 2 May 2023 / Online: 2 May 2023 (03:54:14 CEST)

Extensive evidence indicates that activation of P2X7 receptor (P2X7R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X7R-expressing cells regulate non-classical protein secretion and transfer bioactive components to other cells, including misfolded proteins, participating in inflammatory and neurodegenerative diseases. In this review, we summarize and discuss the studies addressing the impact of P2X7R activation on extracellular vesicle release and their activities.

P2X7 receptor; extracellular vesicles; inflammation; neurodegeneration

Biology and Life Sciences, Neuroscience and Neurology

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P2x7 Receptor and Extracellular Vesicle Release

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