Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

In-silico Molecular Docking and Bibliometric Analyses of Dyes Used in Photodynamic Therapy in Cervical Cancer

Nasrulla Abdullaevich Shanazarov
ORCID logo ,
Afshin Zare
ORCID logo ,
Nadiar Maratovich Mussin
ORCID logo ,
Rustam Kuanyshbekovich Albayev
,
Asset Askerovich Kaliyev
,
Yerbolat Maratovich Iztleuov
,
Sandugash Bakhytbekovna Smailova
,
Farhad Rahmanifar
,
Nazanin Jafari
,
Hanieh Baneshi
,
Amin Tamadon
* ORCID logo
Version 1 : Received: 29 April 2023 / Approved: 30 April 2023 / Online: 30 April 2023 (02:31:30 CEST)

How to cite: Shanazarov, N. A.; Zare, A.; Mussin, N. M.; Albayev, R. K.; Kaliyev, A. A.; Iztleuov, Y. M.; Smailova, S. B.; Rahmanifar, F.; Jafari, N.; Baneshi, H.; Tamadon, A. In-silico Molecular Docking and Bibliometric Analyses of Dyes Used in Photodynamic Therapy in Cervical Cancer. Preprints 2023, 2023041239. https://doi.org/10.20944/preprints202304.1239.v1 Shanazarov, N. A.; Zare, A.; Mussin, N. M.; Albayev, R. K.; Kaliyev, A. A.; Iztleuov, Y. M.; Smailova, S. B.; Rahmanifar, F.; Jafari, N.; Baneshi, H.; Tamadon, A. In-silico Molecular Docking and Bibliometric Analyses of Dyes Used in Photodynamic Therapy in Cervical Cancer. Preprints 2023, 2023041239. https://doi.org/10.20944/preprints202304.1239.v1

Abstract

Cervical cancer is a significant global health concern, with human papillomavirus (HPV) infection being a crucial risk factor. Photodynamic therapy (PDT) is an attractive, minimally invasive treatment for HPV-related cervical lesions, which uses photosensitizers and light to selectively de-stroy abnormal cells. We aim to provide an overview of the various sorts of dyes that are utilized in PDT for decreasing the incidence and mortality of cervical cancer. Besides, the article discusses ongoing clinical trials for PDT in low-grade squamous intraepithelial neoplasia (LSIL) and high-grade squamous intraepithelial lesions (HSIL), as well as preclinical approaches for PDT in cervical cancer using various dyes. Moreover, it highlights potential dyes for PDT, examine them in in-silico condition, their pros and cons and also the solutions for enhancing their anticancer com-patibility. We also display that PDT is a promising therapeutic strategy for the diagnosis and treatment of HPV-associated cervical lesions. Moreover, it shows that using different classes of dyes improves the anticancer effects of PDT. Finally, among all dyes which are used in PDT, Fullerene demonstrated high tendency to over expressed receptors in cervical cancer cells and seems to be a proper candidate for be used in PDT more than before, but further research is necessary to assess its long-term efficacy and safety.

Keywords

Cervical cancer; Human papillomavirus (HPV); Photodynamic therapy (PDT); Squamous in-traepithelial neoplasia; Bibliometric analysis; Molecular Docking; Fullerene

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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