Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Chasing Circulating Biomarkers in Renal Cell Carcinoma: the Case of Extracellular Vesicles and their miRNA Cargos

Ilenia Mastrolia
* ORCID logo ,
Virginia Catani
ORCID logo ,
Marco Oltrecolli
,
Stefania Pipitone
,
Maria Giuseppa Vitale
,
Valentina Masciale
ORCID logo ,
Chiara Chiavelli
ORCID logo ,
Carlo Augusto Bortolotti
ORCID logo ,
Cecilia Nasso
,
Giulia Grisendi
,
Roberto Sabbatini
,
Massimo Dominici
*
Version 1 : Received: 28 April 2023 / Approved: 28 April 2023 / Online: 28 April 2023 (13:00:31 CEST)

A peer-reviewed article of this Preprint also exists.

Mastrolia, I.; Catani, V.; Oltrecolli, M.; Pipitone, S.; Vitale, M.G.; Masciale, V.; Chiavelli, C.; Bortolotti, C.A.; Nasso, C.; Grisendi, G.; Sabbatini, R.; Dominici, M. Chasing the Role of miRNAs in RCC: From Free-Circulating to Extracellular-Vesicle-Derived Biomarkers. Biology 2023, 12, 877. Mastrolia, I.; Catani, V.; Oltrecolli, M.; Pipitone, S.; Vitale, M.G.; Masciale, V.; Chiavelli, C.; Bortolotti, C.A.; Nasso, C.; Grisendi, G.; Sabbatini, R.; Dominici, M. Chasing the Role of miRNAs in RCC: From Free-Circulating to Extracellular-Vesicle-Derived Biomarkers. Biology 2023, 12, 877.

Abstract

Renal cell carcinoma (RCC) is the second most common cancer of the urinary system. The current therapeutic strategies are based on partial or total nephrectomy and/or targeted therapies based on immune checkpoint inhibitors to which patients are often refractory. Preventive and screening strategies are not existing and the few available biomarkers for RCC are characterized by the lack of sensitivity, outlining the need of novel noninvasive and sensitive biomarkers for an early diag-nosis and a better disease monitoring. Blood liquid biopsy (LB) is a non- or minimally invasive procedure for a more representative view of tumor heterogeneity than the tissue biopsy, poten-tially allowing real-time monitoring of cancer evolution. Growing interest is focused on the extra-cellular vesicles (EVs) secreted by either healthy or tumoral cells and recovered in a variety of bio-logical matrices, blood included. EVs are involved in cell-to-cell crosstalk transferring their mRNAs, miRNAs, and proteins content. In particular, transferred miRNAs may regulate the tu-morigenesis and proliferation also impacting on resistance to apoptosis, thus representing poten-tial useful biomarkers. Here we present the latest efforts in the identification of circulating miR-NAs in blood samples, focusing on the potential use of EV derived miRNAs as RCC diagnostic, prognostic markers.

Keywords

renal cell carcinoma; liquid biopsy; blood; extracellular vesicles; microRNA; biomarker; diagnostics; prognosis; prediction

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.