PreprintCommunicationVersion 1Preserved in Portico This version is not peer-reviewed
The Implication of ATP Scavenging Behaviour and Upregulation of Immune Regulatory Receptor by Intracellular Porphyromonas gingivalis Based on In-Vitro Models on the Prognosis of Digestive Tract Cancers Regarding the Oral Cancer Patients
Version 1
: Received: 24 April 2023 / Approved: 25 April 2023 / Online: 25 April 2023 (07:05:39 CEST)
How to cite:
Perera, M.; Perera, I. The Implication of ATP Scavenging Behaviour and Upregulation of Immune Regulatory Receptor by Intracellular Porphyromonas gingivalis Based on In-Vitro Models on the Prognosis of Digestive Tract Cancers Regarding the Oral Cancer Patients. Preprints2023, 2023040892. https://doi.org/10.20944/preprints202304.0892.v1
Perera, M.; Perera, I. The Implication of ATP Scavenging Behaviour and Upregulation of Immune Regulatory Receptor by Intracellular Porphyromonas gingivalis Based on In-Vitro Models on the Prognosis of Digestive Tract Cancers Regarding the Oral Cancer Patients. Preprints 2023, 2023040892. https://doi.org/10.20944/preprints202304.0892.v1
Perera, M.; Perera, I. The Implication of ATP Scavenging Behaviour and Upregulation of Immune Regulatory Receptor by Intracellular Porphyromonas gingivalis Based on In-Vitro Models on the Prognosis of Digestive Tract Cancers Regarding the Oral Cancer Patients. Preprints2023, 2023040892. https://doi.org/10.20944/preprints202304.0892.v1
APA Style
Perera, M., & Perera, I. (2023). The Implication of ATP Scavenging Behaviour and Upregulation of Immune Regulatory Receptor by Intracellular Porphyromonas gingivalis Based on In-Vitro Models on the Prognosis of Digestive Tract Cancers Regarding the Oral Cancer Patients. Preprints. https://doi.org/10.20944/preprints202304.0892.v1
Chicago/Turabian Style
Perera, M. and Irosha Perera. 2023 "The Implication of ATP Scavenging Behaviour and Upregulation of Immune Regulatory Receptor by Intracellular Porphyromonas gingivalis Based on In-Vitro Models on the Prognosis of Digestive Tract Cancers Regarding the Oral Cancer Patients" Preprints. https://doi.org/10.20944/preprints202304.0892.v1
Abstract
At present there is a huge demand for experimental periodontal models to expand the knowledge in periodontal health related to Microbiome Medicine. Thus far none of the periodontal pathogens or cocktail of pathogens reported as aetiological agents of infectious chronic periodontitis to link with oral squamous cell carcinoma as the way Helicobactor pyroli linked with gastric carcinoma and other related gastric malignancies. Nevertheless, invasive pathogenic mechanisms of virulent strains of Porphyromonas gingivalis and Fusobacterium nucleatum singly as well as a duo demonstrated the progression and devastation of oral, pancreatic, and colorectal cancers in different study populations. Periodontal disease may be an inevitable consequence or complication of oral cancer patients who comprise a section of digestive tract cancers, due to suboptimal or poor oral hygiene practices due to unbearable pain and other complications of stage four oral cancer. Periodontitis is a reversible oral condition when it is treated properly at the correct stage and good oral hygiene practices and treating chronic periodontitis showed successful interventions in the prognosis of oral cancer. In the light of these scientifically proven epidemiological, laboratory, and clinical evidence this communication highlights the implication of ATP scavenging behavior and upregulation of immune regulatory receptors by intracellular Porphyromonas gingivalis based on in-vitro models on the prognosis of digestive tract cancers regarding the oral cancer patients.
Keywords
Porphyromonas gingivalis; ATP scavenging behavior; Microbiome Medicine; Digestive tract cancers
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
