Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Optimal Nutritional Support Strategy based on the Association between Modified NUTRIC Score and 28-Day Mortality in Critically ill Patients: A Prospective Study

Sunny Park
ORCID logo ,
So hyang Park
,
Ye ju Kim
,
Geon Ho Lee
,
Hyung-Sook Kim
ORCID logo ,
Sung Yoon Lim
*,† ,
Soo An Choi
*,† ORCID logo
†
These authors contributed equally to this work.
Version 1 : Received: 17 April 2023 / Approved: 18 April 2023 / Online: 18 April 2023 (03:40:37 CEST)

A peer-reviewed article of this Preprint also exists.

Park, S.; Park, S.H.; Kim, Y.; Lee, G.H.; Kim, H.-S.; Lim, S.Y.; Choi, S.A. Optimal Nutritional Support Strategy Based on the Association between Modified NUTRIC Score and 28-Day Mortality in Critically Ill Patients: A Prospective Study. Nutrients 2023, 15, 2465. Park, S.; Park, S.H.; Kim, Y.; Lee, G.H.; Kim, H.-S.; Lim, S.Y.; Choi, S.A. Optimal Nutritional Support Strategy Based on the Association between Modified NUTRIC Score and 28-Day Mortality in Critically Ill Patients: A Prospective Study. Nutrients 2023, 15, 2465.

Abstract

Background: Malnutrition in critically ill paitents is closely linked with clinical outcomes. During acute inflammatory states, nutrition cannot reverse the loss of body cell mass completely. Studies on nutritional screening and strategy considering metabolic changes not yet been conducted. We aimed to identify nutrition strategies using the modified Nutrition Risk in the Critically ill (mNUTIRC) score. Methods: Nutrition support data, laboratory nutrition indicators, and prognosis indices were prospectively collected on the 2nd and 7th day after admission. It is to identify the effect of changes on the metabolic status and critical target of nutrition intervention. To discriminate the high-risk group of malnutrition, receiver operating characteristic curves were plotted. Risk factors associated with 28 day-mortality were evaluated using multivariable Cox proportional hazards regression. Results: A total of 490 and 266 patients were analyzed on the 2nd and 7th day, respectively. Only the mNUTRIC score showed significant differences in nutritional risk stratification. The use of vasopressors, hypo-protein supply (< 1.0 g/kg/day), high mNUTRIC score and hypoalbuminemia (<2.5 mg/dl) in the recovery phase was strongly associated with 28-day mortality. Conclusions: The implementation of the mNUTRIC score and protein supply in the post-acute phase is critical to improve 28-day mortality in critically ill patients.

Keywords

critically ill patients; 28-day mortality; modified NUTRIC score; nutrition screening tool; nutritionsl support strategy

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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