Version 1
: Received: 23 February 2023 / Approved: 27 February 2023 / Online: 27 February 2023 (13:33:51 CET)
Version 2
: Received: 19 May 2023 / Approved: 22 May 2023 / Online: 22 May 2023 (13:56:53 CEST)
How to cite:
Da Silva, T.L.; Dias, A.R.N.; Quaresma, J.A.S.; Falcão, L.F.M. Liver Fibrosis in Individuals With Hepatitis C Virus Genotype 1B From Brazilian Eastern Amazon. Preprints2023, 2023020475. https://doi.org/10.20944/preprints202302.0475.v1
Da Silva, T.L.; Dias, A.R.N.; Quaresma, J.A.S.; Falcão, L.F.M. Liver Fibrosis in Individuals With Hepatitis C Virus Genotype 1B From Brazilian Eastern Amazon. Preprints 2023, 2023020475. https://doi.org/10.20944/preprints202302.0475.v1
Da Silva, T.L.; Dias, A.R.N.; Quaresma, J.A.S.; Falcão, L.F.M. Liver Fibrosis in Individuals With Hepatitis C Virus Genotype 1B From Brazilian Eastern Amazon. Preprints2023, 2023020475. https://doi.org/10.20944/preprints202302.0475.v1
APA Style
Da Silva, T.L., Dias, A.R.N., Quaresma, J.A.S., & Falcão, L.F.M. (2023). Liver Fibrosis in Individuals With Hepatitis C Virus Genotype 1B From Brazilian Eastern Amazon. Preprints. https://doi.org/10.20944/preprints202302.0475.v1
Chicago/Turabian Style
Da Silva, T.L., Juarez Antônio Simões Quaresma and Luiz Fábio Magno Falcão. 2023 "Liver Fibrosis in Individuals With Hepatitis C Virus Genotype 1B From Brazilian Eastern Amazon" Preprints. https://doi.org/10.20944/preprints202302.0475.v1
Abstract
INTRODUCTION Hepatitis C virus (HCV) has a high genetic diversity, with seven genotypes with 86 subtypes. This genetic variability confers persistence in the infection and escape of the immune system with evolution to cirrhosis and cancer. Environmental factors can contribute to different disease progression, being essential to assess the viral genotype in the infection and discuss the environmental particularities of Eastern Amazon, and the frequencies of Liver fibrosis between different HCV genotypes in patients living in a region of the Brazilian Eastern Brazilian Amazon. METHODS Consists in an observational cross-sectional study. Sociodemographic and clinical data of 76 individuals diagnosed with Hepatitis C between 2019 and 2020 in public health services were selected. Data collected was tabulated in Microsoft Excel 2010TM spreadsheets and analysed in GraphPad Prism 5.0TM. Liver fibrosis was associated with genetic subtypes. RESULTS Subtype 1b was predominant (42.1%), followed by 1a (13%) and 3a (1.3%). 69.7% of participants had chronic hepatitis, with mild fibrosis (F1/F2) being the most prevalent (38.1%). Severe fibrosis was detected in 75% of individuals infected with the subtype 1b, that is associated with more severe disease. CONCLUSIONS We suggest further studies, to assess other communities in the region, as well as the monitoring of these patients with Liver Elastography to determine the disease evolution and its better management.
Keywords
Hepatitis C virus; Genetic; Chronic Hepatitis C; Liver, Elastography
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
