Version 1
: Received: 6 February 2023 / Approved: 13 February 2023 / Online: 13 February 2023 (02:06:22 CET)
Version 2
: Received: 15 September 2023 / Approved: 18 September 2023 / Online: 18 September 2023 (10:11:39 CEST)
How to cite:
Dong, S.X.M. Novel Data Analyses Explain the Birth-Cohort Phenomenon of Peptic Ulcers. Preprints2023, 2023020193. https://doi.org/10.20944/preprints202302.0193.v1
Dong, S.X.M. Novel Data Analyses Explain the Birth-Cohort Phenomenon of Peptic Ulcers. Preprints 2023, 2023020193. https://doi.org/10.20944/preprints202302.0193.v1
Dong, S.X.M. Novel Data Analyses Explain the Birth-Cohort Phenomenon of Peptic Ulcers. Preprints2023, 2023020193. https://doi.org/10.20944/preprints202302.0193.v1
APA Style
Dong, S.X.M. (2023). Novel Data Analyses Explain the Birth-Cohort Phenomenon of Peptic Ulcers. Preprints. https://doi.org/10.20944/preprints202302.0193.v1
Chicago/Turabian Style
Dong, S.X.M. 2023 "Novel Data Analyses Explain the Birth-Cohort Phenomenon of Peptic Ulcers" Preprints. https://doi.org/10.20944/preprints202302.0193.v1
Abstract
Background:The birth-cohort phenomenon of peptic ulcers has remained an unresolved mystery for 60 years since it was first reported in 1962. Currently, peptic ulcers are widely studied as an infectious disease caused by Helicobacter pylori, but this etiology cannot explain this phenomenon. A recently published etiological theory identified peptic ulcers as a psychosomatic disease triggered by psychological stress. This new theory addresses all the characteristics, observations/phenomena, controversies, and mysteries of the disease in a series of 6 articles. Methods:In this fourth article of the series, all the possible causes of peptic ulcers collected from literatures were classified into 3 categories, and the mortality rates caused by these categories were superposed to reproduce the fluctuation curves in the birth-cohort phenomenon. Results:The fluctuation curves in the birth-cohort phenomenon were successfully reproduced, with all the details of the phenomenon elucidated. Psychological stress induced by the First World War accounted for the increasing mortality rates in the early 1910s. The high mortality rates between 1910s and 1940s were maintained by a succession of crucial events that led to extensive psychological stress in the population. The end of the Second World War and continuous improvements in living conditions explained the fall in the early 1950s and afterwards. Conclusions:The birth-cohort phenomenon cannot be fully understood unless peptic ulcers are considered a psychosomatic disease triggered by psychological stress. A full explanation of the birth-cohort phenomenon exemplifies the application of a brand-new methodological concept, superposition mechanism, which can be universally applied to understand any life phenomenon and human disease.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
