Version 1
: Received: 12 January 2023 / Approved: 12 January 2023 / Online: 12 January 2023 (09:06:18 CET)
How to cite:
Widyarti, S.; Wibowo, S.; Sabarudin, A.; Abhirama, I.; Bambang Sumitro, S. Multiple System Atrophy : Mitochondria Dysregulation, Reprogramming and Alternative of Neuroprotective Agents. Preprints2023, 2023010220. https://doi.org/10.20944/preprints202301.0220.v1
Widyarti, S.; Wibowo, S.; Sabarudin, A.; Abhirama, I.; Bambang Sumitro, S. Multiple System Atrophy : Mitochondria Dysregulation, Reprogramming and Alternative of Neuroprotective Agents. Preprints 2023, 2023010220. https://doi.org/10.20944/preprints202301.0220.v1
Widyarti, S.; Wibowo, S.; Sabarudin, A.; Abhirama, I.; Bambang Sumitro, S. Multiple System Atrophy : Mitochondria Dysregulation, Reprogramming and Alternative of Neuroprotective Agents. Preprints2023, 2023010220. https://doi.org/10.20944/preprints202301.0220.v1
APA Style
Widyarti, S., Wibowo, S., Sabarudin, A., Abhirama, I., & Bambang Sumitro, S. (2023). Multiple System Atrophy : Mitochondria Dysregulation, Reprogramming and Alternative of Neuroprotective Agents. Preprints. https://doi.org/10.20944/preprints202301.0220.v1
Chicago/Turabian Style
Widyarti, S., Intan Abhirama and Sutiman Bambang Sumitro. 2023 "Multiple System Atrophy : Mitochondria Dysregulation, Reprogramming and Alternative of Neuroprotective Agents" Preprints. https://doi.org/10.20944/preprints202301.0220.v1
Abstract
Aprogressive and chronic neurological condition called MSA (Multiple System Atrophy) is characterized clinically by varying degrees of dysautonomia, cerebellar ataxia, and parkinsonism. The concept of mitochondrial dysregulation in MSA is one perspective in handling this neurodegenerative disease. Damage to functional mitochondria is driven by the presence of ɑ-Synuclein-induced mitochondrial localization. The goal of MSA treatment up until now has been to reduce symptoms. One of the innovations in the treatment of MSA could be the novel idea based on mitochondrial reprogramming pathways. Mitochondrial reprogramming can be done in various ways in which the use of hydrogen, magnesium and low-dose hydrogen peroxide.
Keywords
Hydrogen, Mitochondrial Dysregulation, MSA, Multiple System Atrophy
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
