It was estimated the proportion and number of invasive cancer cases and deaths for 26 cancer types in adults aged 30 years and older in the United States in 2014. In this study was found that these cancers were attributable to modifiable risk factors such as cigarette smoking, second-hand smoke, alcohol intake, physical inactivity, excess body weight, red and processed meat consumption, low consumption of vegetables and fruits, dietary calcium, and ultraviolet radiation and six cancer-associated infections. Several databases were reviewed including PUBMED, Google scholar, and Web of Science. The facts suggest that a number of individuals in the US present risk factors for cancer, which development in malignancies would ultimately depend on the interaction of environmental and genetic factors.