Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy

Robert H. Eibl; Markus Schneemann

doi:10.20944/preprints202212.0300.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 15 December 2022 / Approved: 16 December 2022 / Online: 16 December 2022 (08:47:35 CET)

A recent paradigm shift in diagnostics of medulloblastoma allows the distinction of four major groups defined by genetic data rather than histology. This new molecular classification correlates better with prognosis and will allow better clinical management for therapies targeting druggable mutations, but also offers a new combination of monitoring tumor development in real-time and treatment response by sequential liquid biopsy. This review highlights recent developments after a century of milestones in neurosurgery, radio- and chemotherapy, but also controversial theories on the cell of origin, animal models and the use of liquid biopsy.

medulloblastoma; TP53 mutation; molecular classification; diagnostics; liquid biopsy; animal models; transcriptome; precision oncology

Biology and Life Sciences, Biochemistry and Molecular Biology

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Medulloblastoma: From TP53 Mutations to Molecular Classification and Liquid Biopsy

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