Version 1
: Received: 3 December 2022 / Approved: 7 December 2022 / Online: 7 December 2022 (09:19:10 CET)
How to cite:
Popovic, M. Never Ending Story? Biothermodynamic Properties of Biosynthesis and Binding of Omicron BQ.1, BQ.1.1, XBB and XBB.1 variants of SARS-CoV-2. Preprints2022, 2022120122. https://doi.org/10.20944/preprints202212.0122.v1
Popovic, M. Never Ending Story? Biothermodynamic Properties of Biosynthesis and Binding of Omicron BQ.1, BQ.1.1, XBB and XBB.1 variants of SARS-CoV-2. Preprints 2022, 2022120122. https://doi.org/10.20944/preprints202212.0122.v1
Popovic, M. Never Ending Story? Biothermodynamic Properties of Biosynthesis and Binding of Omicron BQ.1, BQ.1.1, XBB and XBB.1 variants of SARS-CoV-2. Preprints2022, 2022120122. https://doi.org/10.20944/preprints202212.0122.v1
APA Style
Popovic, M. (2022). Never Ending Story? Biothermodynamic Properties of Biosynthesis and Binding of Omicron BQ.1, BQ.1.1, XBB and XBB.1 variants of SARS-CoV-2. Preprints. https://doi.org/10.20944/preprints202212.0122.v1
Chicago/Turabian Style
Popovic, M. 2022 "Never Ending Story? Biothermodynamic Properties of Biosynthesis and Binding of Omicron BQ.1, BQ.1.1, XBB and XBB.1 variants of SARS-CoV-2" Preprints. https://doi.org/10.20944/preprints202212.0122.v1
Abstract
RNA viruses exhibit a great tendency to mutate. Starting from 2019, the wild type that was labeled Hu-1 has during the last 3 years evolved to produce several dozen new variants, as a consequence of mutations. Mutations cause changes in empirical formulas of new virus strains, which lead to change in thermodynamic properties of biosynthesis and binding. These changes cause changes in the rate of reactions of binding of virus antigen to the host cell receptor and the rate of virus multiplication in the host cell. Changes in thermodynamic and kinetic parameters lead to changes in biological parameters of infectivity and pathogenicity. SARS-CoV-2 has starting from in 2019, until today, evolved towards increase in infectivity and maintaining constant pathogenicity, or for some variants a slight decrease in pathogenicity. In the case of Omicron BQ.1, BQ.1.1, XBB and XBB.1 variants pathogenicity is identical as in the Omicron BA.2.75 variant. On the other hand, infectivity of the Omicron BQ.1, BQ.1.1, XBB and XBB.1 variants is greater than those of previous variants. This will most likely result in the phenomenon of asymmetric coinfection, that is circulation of several variants in the population, some being dominant.
Keywords
COVID-19; Elemental composition; Gibbs energy of biosynthesis; Gibbs energy of binding; Variant of concern (VOC)
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
