Arkas, M.; Vardavoulias, M.; Kythreoti, G.; Giannakoudakis, D.A. Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution. Pharmaceutics2023, 15, 524.
Arkas, M.; Vardavoulias, M.; Kythreoti, G.; Giannakoudakis, D.A. Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution. Pharmaceutics 2023, 15, 524.
Arkas, M.; Vardavoulias, M.; Kythreoti, G.; Giannakoudakis, D.A. Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution. Pharmaceutics2023, 15, 524.
Arkas, M.; Vardavoulias, M.; Kythreoti, G.; Giannakoudakis, D.A. Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution. Pharmaceutics 2023, 15, 524.
Abstract
The capability of radially polymerized bio-dendrimers and hyperbranched polymers for medical applications is well established. Among them, perhaps the most important are those that involve interactions with the regenerative mechanisms of cells. Dendritic polymers due to their distinctive architecture may play a multitude of roles such as protein biomimicry (collagen, elastin, hydroxy apatite production), gene and drug delivery (cell differentiation, antimicrobial protection), surface chemistry and charge modulation (adhesion to cells and tissues), polymer cross-linking (eye, skin and internal organ wound healing). The review highlights all the different categories of hard and soft tissues that may be remediated with their contribution. The reader will be also exposed to the incorporation methods to established biomaterials such as scaffolds, the functionalization strategies, and the synthetic paths for the assembly from biocompatible building blocks and natural metabolites.
Chemistry and Materials Science, Medicinal Chemistry
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