Version 1
: Received: 17 October 2022 / Approved: 19 October 2022 / Online: 19 October 2022 (11:30:49 CEST)
How to cite:
Álvarez, L.; Rentero-Garrido, P.; Marín-García, P.; Llobat, L. Interleukin 6 and Interferon Gamma Haplotypes Are Related to Cytokine Serum Levels in Dogs in an Endemic Leishmania infantum Region. Preprints2022, 2022100286. https://doi.org/10.20944/preprints202210.0286.v1
Álvarez, L.; Rentero-Garrido, P.; Marín-García, P.; Llobat, L. Interleukin 6 and Interferon Gamma Haplotypes Are Related to Cytokine Serum Levels in Dogs in an Endemic Leishmania infantum Region. Preprints 2022, 2022100286. https://doi.org/10.20944/preprints202210.0286.v1
Álvarez, L.; Rentero-Garrido, P.; Marín-García, P.; Llobat, L. Interleukin 6 and Interferon Gamma Haplotypes Are Related to Cytokine Serum Levels in Dogs in an Endemic Leishmania infantum Region. Preprints2022, 2022100286. https://doi.org/10.20944/preprints202210.0286.v1
APA Style
Álvarez, L., Rentero-Garrido, P., Marín-García, P., & Llobat, L. (2022). Interleukin 6 and Interferon Gamma Haplotypes Are Related to Cytokine Serum Levels in Dogs in an Endemic <em>Leishmania infantum </em>Region. Preprints. https://doi.org/10.20944/preprints202210.0286.v1
Chicago/Turabian Style
Álvarez, L., Pablo-Jesús Marín-García and Lola Llobat. 2022 "Interleukin 6 and Interferon Gamma Haplotypes Are Related to Cytokine Serum Levels in Dogs in an Endemic <em>Leishmania infantum </em>Region" Preprints. https://doi.org/10.20944/preprints202210.0286.v1
Abstract
Background: The Ibizan Hound is a canine breed native to the Mediterranean region, where leishmaniasis is an endemic zoonosis. Several studies indicate a low prevalence of this disease in dogs, whereas other canine breeds present a high prevalence. However, the molecular underlaying mechanisms yet remains unknown. Methods: In this study, we analyze the haplotypes of genes encode cytokines related to immune response of Leishmania infantum infection in twenty-four Boxer and twenty-four Ibizan hound apparently healthy using CanineHD DNA Analysis BeadChip including 165,480 mapped positions. Results: The results show that several haplotypes of genes encoding Interleukin 6 (IL6) and Interferon gamma (IFNG) are related to Interferon gamma (IFN-γ), and Interleukins (IL) 2 and 18 serum levels. Our results indicate that the regulation of immune response is different in the two canine breeds analyzed and are related to the haplotype compositions of the genes encoding these cytokines. Conclusions: Future studies are needed to elucidate whether these differences and haplotypes are related to different phenotypes in immune response and expression gene regulation to L. infantum infection in dogs.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
