Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Version 1 : Received: 28 September 2022 / Approved: 30 September 2022 / Online: 30 September 2022 (11:13:06 CEST)
Version 2 : Received: 31 October 2022 / Approved: 1 November 2022 / Online: 1 November 2022 (09:55:10 CET)

A peer-reviewed article of this Preprint also exists.

Poller, W.; Heidecker, B.; Ammirati, E.; Kuss, A.W.; Tzvetkova, A.; Poller, W.C.; Skurk, C.; Haghikia, A. Innate Immunity in Cardiovascular Diseases—Identification of Novel Molecular Players and Targets. Journal of Clinical Medicine 2023, 12, 335, doi:10.3390/jcm12010335. Poller, W.; Heidecker, B.; Ammirati, E.; Kuss, A.W.; Tzvetkova, A.; Poller, W.C.; Skurk, C.; Haghikia, A. Innate Immunity in Cardiovascular Diseases—Identification of Novel Molecular Players and Targets. Journal of Clinical Medicine 2023, 12, 335, doi:10.3390/jcm12010335.

Abstract

During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

Keywords

Immunology; innate immunity; immunogenetics; noncoding genome; tRNA biology; evolutionary genetics (list 3-10 specific to the article yet reasonably common within the subject discipline)

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

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