Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

T-cytotoxic Expression of Leukocyte-Associated Immunoglobulin-like Receptor-1 (LAIR-1) in post-HCV Hepatocellular Carcinoma

Reham Hammad
ORCID logo ,
Reda Badr Aglan
,
Shaymaa A. Mohammed
,
Eman Abu-elnasr Awad
,
Marwa A. Elsaid
,
Hanan .M. Bedair
,
Seham K. Khirala
,
Mohamed A. Selim
,
Asmaa A. Abo Elqasem
ORCID logo ,
Areej Rushdi
ORCID logo ,
Mohamed Ali
ORCID logo ,
Omaima I Abo-Elkheir
,
Eman F. Sanad
ORCID logo ,
Nadia M. Hamdy
* ORCID logo
Version 1 : Received: 15 August 2022 / Approved: 17 August 2022 / Online: 17 August 2022 (11:38:10 CEST)

A peer-reviewed article of this Preprint also exists.

Hammad, R.; Aglan, R.B.; Mohammed, S.A.; Awad, E.A.-E.; Elsaid, M.A.; Bedair, H.M.; Khirala, S.K.; Selim, M.A.; Abo Elqasem, A.A.; Rushdi, A.; Ali, M.; Abo-Elkheir, O.I.; Sanad, E.F.; Hamdy, N.M. Cytotoxic T Cell Expression of Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) in Viral Hepatitis C-Mediated Hepatocellular Carcinoma. Int. J. Mol. Sci. 2022, 23, 12541. Hammad, R.; Aglan, R.B.; Mohammed, S.A.; Awad, E.A.-E.; Elsaid, M.A.; Bedair, H.M.; Khirala, S.K.; Selim, M.A.; Abo Elqasem, A.A.; Rushdi, A.; Ali, M.; Abo-Elkheir, O.I.; Sanad, E.F.; Hamdy, N.M. Cytotoxic T Cell Expression of Leukocyte-Associated Immunoglobulin-Like Receptor-1 (LAIR-1) in Viral Hepatitis C-Mediated Hepatocellular Carcinoma. Int. J. Mol. Sci. 2022, 23, 12541.

Abstract

Background and Aim. Since virus-related hepatocellular carcinoma (HCC) pathogenesis involves liver inflammation, therefore, post-hepatitis C virus (HCV) infection would be a cause for liver cirrhosis that would progress to HCC. Cytotoxic T cells (Tc) are known to be involved in post-HCV complications and HCC pathogenesis. The inhibitory checkpoint Leukocyte-Associated Immunoglobulin-like Receptor-1 (LAIR-1) is expressed on Tc. Therefore, we aimed to determine whether the Tc expression level of LAIR-1 is associated with HCC progression post-HCV and moreover, to evaluate LAIR-1 expression as a non-invasive biomarker for HCC progression in the context of liver cirrhosis post-HCV genotype 4 (G4) in Egyptian patients’ peripheral venous blood liquid biopsy. We studied LAIR-1 expression on Tc related to the progression of liver cirrhosis in a case-controlled study enrolled 64 patients with post-HCV G4-HCC and 37 patients with post-HCV G4-liver cirrhosis. Methods: LAIR-1 expression was analyzed by flow cytometry. Results: LAIR-1 expression on Tc and the percentage of Tc positive for LAIR-1 (LAIR-1+Tc %) were significantly higher in the post-HCV G4-HCC group compared to the post-HCV G4-liver cirrhosis

Keywords

T cytotoxic cells; Leukocyte-associated Immunoglobulin-like Receptor-1; LAIR-1; Hepatitis C virus genotype 4; HCV G4; hepatocellular carcinoma; cirrhosis; immune inhibitory checkpoints; inflammation; prognosis; insulin resistance

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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