Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

T-cytotoxic Expression of Leukocyte-Associated Immunoglobulin-like Receptor-1 (LAIR-1) in post-HCV Hepatocellular Carcinoma

Version 1 : Received: 15 August 2022 / Approved: 17 August 2022 / Online: 17 August 2022 (11:38:10 CEST)

How to cite: Hammad, R.; Aglan, R.B.; Mohammed, S.A.; Awad, E.A.; Elsaid, M.A.; Bedair, H...; Khirala, S.K.; Selim, M.A.; Abo Elqasem, A.A.; Rushdi, A.; Ali, M.; Abo-Elkheir, O.I.; Sanad, E.F.; Hamdy, N.M. T-cytotoxic Expression of Leukocyte-Associated Immunoglobulin-like Receptor-1 (LAIR-1) in post-HCV Hepatocellular Carcinoma. Preprints 2022, 2022080324 (doi: 10.20944/preprints202208.0324.v1). Hammad, R.; Aglan, R.B.; Mohammed, S.A.; Awad, E.A.; Elsaid, M.A.; Bedair, H...; Khirala, S.K.; Selim, M.A.; Abo Elqasem, A.A.; Rushdi, A.; Ali, M.; Abo-Elkheir, O.I.; Sanad, E.F.; Hamdy, N.M. T-cytotoxic Expression of Leukocyte-Associated Immunoglobulin-like Receptor-1 (LAIR-1) in post-HCV Hepatocellular Carcinoma. Preprints 2022, 2022080324 (doi: 10.20944/preprints202208.0324.v1).

Abstract

Background and Aim. Since virus-related hepatocellular carcinoma (HCC) pathogenesis involves liver inflammation, therefore, post-hepatitis C virus (HCV) infection would be a cause for liver cirrhosis that would progress to HCC. Cytotoxic T cells (Tc) are known to be involved in post-HCV complications and HCC pathogenesis. The inhibitory checkpoint Leukocyte-Associated Immunoglobulin-like Receptor-1 (LAIR-1) is expressed on Tc. Therefore, we aimed to determine whether the Tc expression level of LAIR-1 is associated with HCC progression post-HCV and moreover, to evaluate LAIR-1 expression as a non-invasive biomarker for HCC progression in the context of liver cirrhosis post-HCV genotype 4 (G4) in Egyptian patients’ peripheral venous blood liquid biopsy. We studied LAIR-1 expression on Tc related to the progression of liver cirrhosis in a case-controlled study enrolled 64 patients with post-HCV G4-HCC and 37 patients with post-HCV G4-liver cirrhosis. Methods: LAIR-1 expression was analyzed by flow cytometry. Results: LAIR-1 expression on Tc and the percentage of Tc positive for LAIR-1 (LAIR-1+Tc %) were significantly higher in the post-HCV G4-HCC group compared to the post-HCV G4-liver cirrhosis

Keywords

T cytotoxic cells; Leukocyte-associated Immunoglobulin-like Receptor-1; LAIR-1; Hepatitis C virus genotype 4; HCV G4; hepatocellular carcinoma; cirrhosis; immune inhibitory checkpoints; inflammation; prognosis; insulin resistance

Subject

LIFE SCIENCES, Immunology

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