Olatunde, A.C.; Cornwall, D.H.; Roedel, M.; Lamb, T.J. Mouse Models for Unravelling Immunology of Blood Stage Malaria. Vaccines2022, 10, 1525.
Olatunde, A.C.; Cornwall, D.H.; Roedel, M.; Lamb, T.J. Mouse Models for Unravelling Immunology of Blood Stage Malaria. Vaccines 2022, 10, 1525.
Olatunde, A.C.; Cornwall, D.H.; Roedel, M.; Lamb, T.J. Mouse Models for Unravelling Immunology of Blood Stage Malaria. Vaccines2022, 10, 1525.
Olatunde, A.C.; Cornwall, D.H.; Roedel, M.; Lamb, T.J. Mouse Models for Unravelling Immunology of Blood Stage Malaria. Vaccines 2022, 10, 1525.
Abstract
Malaria comprises a spectrum of disease syndromes and the immune system is a major participant in malarial disease. This is particularly true in relation to the immune responses elicited against blood stages of Plasmodium-parasites that are responsible for the pathogenesis of infection. Mouse models of malaria are commonly used to dissect the immune mechanisms underlying disease. While no one mouse model of Plasmodium infection completely recapitulates all the features of malaria in humans, collectively the existing models are invaluable for defining the events that lead to the immunopathogenesis of malaria. Here we review the different mouse models of Plasmodium infection that are available, and highlight some of the main contributions these models have made with regards to identifying immune mechanisms of parasite control and the immunopathogenesis of malaria.
Keywords
mouse models; Plasmodium; Adaptive immunity; Innate immunity; T cells; B cells; Macrphages; Neutrophils; Antibodies; Cytokines; parasite control; immunopathogensis
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
