Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Rogue T Cells and LncRNAs: Two Strong Contenders for Autoimmune Disorders

Version 1 : Received: 26 June 2022 / Approved: 1 July 2022 / Online: 1 July 2022 (03:49:07 CEST)

How to cite: Kandimalla, G.; Parmar, S.; Singh, P.K.; Manhas, V.D.; Vuree, S. Rogue T Cells and LncRNAs: Two Strong Contenders for Autoimmune Disorders. Preprints 2022, 2022070001. https://doi.org/10.20944/preprints202207.0001.v1 Kandimalla, G.; Parmar, S.; Singh, P.K.; Manhas, V.D.; Vuree, S. Rogue T Cells and LncRNAs: Two Strong Contenders for Autoimmune Disorders. Preprints 2022, 2022070001. https://doi.org/10.20944/preprints202207.0001.v1

Abstract

The importance of a properly regulated immune response has been explored through various research-oriented methods. It has proved that having an effective and well-regulated immune response helps prevent many minors and serious diseases. Any kind of dysregulation in the working of the immune system may lead to severe consequences. An autoimmune disorder is one such consequence in which the component of the immune system starts targeting self-cells of the body, treating them as self-antigen producing autoantibodies and immune complexes resulting from the failure of immune responses both at a central and peripheral level. Currently, many autoimmune disorders are prevailing across the world, and new diseases need attention.In this review, we have written about the functions of T cell, LncRNAs and also some interactions between the LncRNAs and miRNAs in the pathogenesis of Multiple sclerosis (MS), Systemic lupus erythematosus (SLE), Type 1 diabetes (T1D), Rheumatoid arthritis (RA). To find the functions of these autoimmune disorders we have done intensive literature search during this we also found that GAS5 and MALAT are common in MS, SLE, T1D, RA. And finally, we have also mentioned the therapeutic drugs which neutralizes the different cluster of differentiation (CDs) and also suppresses the T cell differentiation in MS, SLE and RA. For T1D therapeutic strategies and various types of insulin are mentioned.

Keywords

autoimmunity; T-Cell; LncRNAs; miRNAs; RA; T1D; MS; SLE

Subject

Biology and Life Sciences, Immunology and Microbiology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.