Version 1
: Received: 26 June 2022 / Approved: 1 July 2022 / Online: 1 July 2022 (03:49:07 CEST)
How to cite:
Kandimalla, G.; Parmar, S.; Singh, P. K.; Manhas, V. D.; Vuree, S. Rogue T Cells and LncRNAs: Two Strong Contenders for Autoimmune Disorders. Preprints2022, 2022070001. https://doi.org/10.20944/preprints202207.0001.v1
Kandimalla, G.; Parmar, S.; Singh, P. K.; Manhas, V. D.; Vuree, S. Rogue T Cells and LncRNAs: Two Strong Contenders for Autoimmune Disorders. Preprints 2022, 2022070001. https://doi.org/10.20944/preprints202207.0001.v1
Kandimalla, G.; Parmar, S.; Singh, P. K.; Manhas, V. D.; Vuree, S. Rogue T Cells and LncRNAs: Two Strong Contenders for Autoimmune Disorders. Preprints2022, 2022070001. https://doi.org/10.20944/preprints202207.0001.v1
APA Style
Kandimalla, G., Parmar, S., Singh, P. K., Manhas, V. D., & Vuree, S. (2022). Rogue T Cells and LncRNAs: Two Strong Contenders for Autoimmune Disorders. Preprints. https://doi.org/10.20944/preprints202207.0001.v1
Chicago/Turabian Style
Kandimalla, G., Vinay Dev Manhas and Sugunakar Vuree. 2022 "Rogue T Cells and LncRNAs: Two Strong Contenders for Autoimmune Disorders" Preprints. https://doi.org/10.20944/preprints202207.0001.v1
Abstract
The importance of a properly regulated immune response has been explored through various research-oriented methods. It has proved that having an effective and well-regulated immune response helps prevent many minors and serious diseases. Any kind of dysregulation in the working of the immune system may lead to severe consequences. An autoimmune disorder is one such consequence in which the component of the immune system starts targeting self-cells of the body, treating them as self-antigen producing autoantibodies and immune complexes resulting from the failure of immune responses both at a central and peripheral level. Currently, many autoimmune disorders are prevailing across the world, and new diseases need attention.In this review, we have written about the functions of T cell, LncRNAs and also some interactions between the LncRNAs and miRNAs in the pathogenesis of Multiple sclerosis (MS), Systemic lupus erythematosus (SLE), Type 1 diabetes (T1D), Rheumatoid arthritis (RA). To find the functions of these autoimmune disorders we have done intensive literature search during this we also found that GAS5 and MALAT are common in MS, SLE, T1D, RA. And finally, we have also mentioned the therapeutic drugs which neutralizes the different cluster of differentiation (CDs) and also suppresses the T cell differentiation in MS, SLE and RA. For T1D therapeutic strategies and various types of insulin are mentioned.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
