Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Biotechnology, Bioengineering and Applications of Bacillus Nattokinase

these authors contributed equally to this work
Version 1 : Received: 29 June 2022 / Approved: 29 June 2022 / Online: 29 June 2022 (09:39:07 CEST)

A peer-reviewed article of this Preprint also exists.

Yuan, L.; Liangqi, C.; Xiyu, T.; Jinyao, L. Biotechnology, Bioengineering and Applications of Bacillus Nattokinase. Biomolecules 2022, 12, 980. Yuan, L.; Liangqi, C.; Xiyu, T.; Jinyao, L. Biotechnology, Bioengineering and Applications of Bacillus Nattokinase. Biomolecules 2022, 12, 980.

Journal reference: Biomolecules 2022, 12, 980
DOI: 10.3390/biom12070980

Abstract

Thrombosis has threatened human health in past decades. Bacillus nattokinase is a potential thrombolytic drug without side-effect and low cost and has been introduced into the consumer market as a functional food or dietary supplement. This review firstly summarizes the biodiversity sources and fermentation process of nattokinase, and systematically expounds the structure, cata-lytic mechanism and enzymatic properties of nattokinase; In view of the problems of low fermen-tation yield, insufficient activity and stability of nattokinase, this review discusses the heterologous expression of nattokinase in different microbial hosts, and summarizes the protein and genetic en-gineering progress of nattokinase-producing strains; Finally, this review summarizes the clinical application of nattokinase.

Keywords

Bacillus nattokinase; Physiological and biochemical characteristics; Molecular structure; Molecular modifcation; Functional food and clinical application

Subject

BIOLOGY, Other

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