Yuan, L.; Liangqi, C.; Xiyu, T.; Jinyao, L. Biotechnology, Bioengineering and Applications of Bacillus Nattokinase. Biomolecules2022, 12, 980.
Yuan, L.; Liangqi, C.; Xiyu, T.; Jinyao, L. Biotechnology, Bioengineering and Applications of Bacillus Nattokinase. Biomolecules 2022, 12, 980.
Yuan, L.; Liangqi, C.; Xiyu, T.; Jinyao, L. Biotechnology, Bioengineering and Applications of Bacillus Nattokinase. Biomolecules2022, 12, 980.
Yuan, L.; Liangqi, C.; Xiyu, T.; Jinyao, L. Biotechnology, Bioengineering and Applications of Bacillus Nattokinase. Biomolecules 2022, 12, 980.
Abstract
Thrombosis has threatened human health in past decades. Bacillus nattokinase is a potential thrombolytic drug without side-effect and low cost and has been introduced into the consumer market as a functional food or dietary supplement. This review firstly summarizes the biodiversity sources and fermentation process of nattokinase, and systematically expounds the structure, cata-lytic mechanism and enzymatic properties of nattokinase; In view of the problems of low fermen-tation yield, insufficient activity and stability of nattokinase, this review discusses the heterologous expression of nattokinase in different microbial hosts, and summarizes the protein and genetic en-gineering progress of nattokinase-producing strains; Finally, this review summarizes the clinical application of nattokinase.
Keywords
Bacillus nattokinase; Physiological and biochemical characteristics; Molecular structure; Molecular modifcation; Functional food and clinical application
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
