Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

[18F]Fluorocholine PET/CT False Positive: Foreign Body Reaction Mimicking Low-Grade Glioma Progression

Version 1 : Received: 7 April 2022 / Approved: 8 April 2022 / Online: 8 April 2022 (08:48:36 CEST)

How to cite: Rudolphi-Solero, T.; Triviño-Ibáñez, E.M.; Martínez-Barbero, J.P.; Cordero-Tous, N.; Chamorro-Santos, C.E.; Rodríguez-Fernández, A.; Gómez-Río, M.M. [18F]Fluorocholine PET/CT False Positive: Foreign Body Reaction Mimicking Low-Grade Glioma Progression. Preprints 2022, 2022040076 (doi: 10.20944/preprints202204.0076.v1). Rudolphi-Solero, T.; Triviño-Ibáñez, E.M.; Martínez-Barbero, J.P.; Cordero-Tous, N.; Chamorro-Santos, C.E.; Rodríguez-Fernández, A.; Gómez-Río, M.M. [18F]Fluorocholine PET/CT False Positive: Foreign Body Reaction Mimicking Low-Grade Glioma Progression. Preprints 2022, 2022040076 (doi: 10.20944/preprints202204.0076.v1).

Abstract

A right frontoparietal neoplastic lesion was found in a young-aged patient with analgesic refractory headache. Surgical resection was performed, and the pathologist analysis turned out a cellular ependymoma with signs of anaplasia. In the follow-up, a MRI showed a suspicious lesion, so a [18F]Fluorocholine PET/CT was performed. An increased uptake was described in the right parietal region on the margin of residual cystic lesion. The patient got a complete resection which was confirmed later by MR. In the pathology analysis, a focally congestive cerebral parenchyma with a central histiocytic reaction to foreign body area was described. Foreign body reaction in brain tissue is a very rare immune response that has not been well studied. Haemostatic material has been reported as a possible trigger of this response in other organs and could be detected by [18F]FDG PET/CT. Following the experience of the current case report, [18F]Fluorocholine PET/CT could also show a false positive related to foreign body reaction.

Keywords

Foreign Body Reaction; deshydroxy-(18F) fluorocholine; Positron Emission Tomography; Low-grade glioma; Haemostatic material

Subject

MEDICINE & PHARMACOLOGY, Oncology & Oncogenics

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